2. Gene
  3. Six3 - sine oculis-related homeobox 3 Gene

Six3 - sine oculis-related homeobox 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Six3a; Six3b; Six3beta; Six3alpha; E130112M24Rik

基因 ID: 20473 | 基因类型: protein coding

关于 Six3

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; lens fiber cell apoptotic process; and neuroblast migration. Acts upstream of or within several processes, including animal organ development; circadian behavior; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including embryo ectoderm; limb; maxillary process; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Six3 基因产物(1)

mRNA Protein Name
NM_011381.4 NP_035511.2 homeobox protein SIX3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12050133 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
17066077 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12569128 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17066077 MGI
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
17666527 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12050133 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8814301 MGI
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
17666527 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic process involved in development IMP
IMP: 通过突变表型推断
18694563 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
12569128 MGI
acts upstream of or within camera-type eye development IGI
IGI: 通过遗传相互作用推断
12072567 MGI
involved in cell proliferation in forebrain IMP
IMP: 通过突变表型推断
18694563 MGI
acts upstream of or within circadian behavior IMP
IMP: 通过突变表型推断
21525287 MGI
acts upstream of or within diencephalon development IGI
IGI: 通过遗传相互作用推断
18094027 MGI
involved in epithelial cell maturation IMP
IMP: 通过突变表型推断
22071110 MGI
acts upstream of or within eye development IDA
IDA: 通过直接分析推断
12050133 MGI
acts upstream of or within forebrain anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
18094027 MGI
acts upstream of or within forebrain anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
18094027 MGI
acts upstream of or within gonad development IGI
IGI: 通过遗传相互作用推断
18775421 MGI
involved in lens development in camera-type eye IDA
IDA: 通过直接分析推断
11139622 MGI
involved in lens fiber cell apoptotic process IDA
IDA: 通过直接分析推断
12072567 MGI
involved in lens fiber cell differentiation IDA
IDA: 通过直接分析推断
12072567 MGI
acts upstream of or within lens induction in camera-type eye IMP
IMP: 通过突变表型推断
17066077 MGI
acts upstream of or within multicellular organism growth IGI
IGI: 通过遗传相互作用推断
18775421 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12050133 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11139622 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IMP
IMP: 通过突变表型推断
12569128 MGI
involved in negative regulation of neuron differentiation IDA
IDA: 通过直接分析推断
17576749 MGI
involved in neuroblast differentiation IMP
IMP: 通过突变表型推断
22071110 MGI
involved in neuroblast migration IMP
IMP: 通过突变表型推断
22071110 MGI
involved in optic vesicle morphogenesis IDA
IDA: 通过直接分析推断
11458394 MGI
acts upstream of or within pituitary gland development IGI
IGI: 通过遗传相互作用推断
18775421 MGI
involved in pituitary gland development IMP
IMP: 通过突变表型推断
18775421 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17066077 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17066077 MGI
acts upstream of or within protein import into nucleus IDA
IDA: 通过直接分析推断
16024294 MGI
involved in proximal/distal axis specification IDA
IDA: 通过直接分析推断
12163408 MGI
involved in regulation of cell cycle phase transition IDA
IDA: 通过直接分析推断
17576749 MGI
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18775421 MGI
involved in regulation of neural precursor cell proliferation IDA
IDA: 通过直接分析推断
17576749 MGI
involved in regulation of neural retina development IMP
IMP: 通过突变表型推断
20890044 MGI
involved in regulation of neuroblast proliferation IMP
IMP: 通过突变表型推断
22071110 MGI
acts upstream of or within telencephalon development IMP
IMP: 通过突变表型推断
18094027 MGI
involved in telencephalon development IMP
IMP: 通过突变表型推断
18694563 MGI
involved in telencephalon regionalization IMP
IMP: 通过突变表型推断
18694563 MGI
acts upstream of or within thyroid gland development IGI
IGI: 通过遗传相互作用推断
18775421 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
8814301 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

homeobox protein SIX3

sine oculis homeobox homolog 3

sine oculis-related homeobox 3 homolog

Six3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Six3 Q62233 Mta1 Mus musculus Q8K4B0
Pull Down
17666527
种属内
Six3 Q62233 Hdac2 Mus musculus P70288
Pull Down
17666527
种属内
Six3 Q62233 Hdac2 Mus musculus P70288
Anti Bait CoIP
17666527
种属内
Six3 Q62233 Tle5 Mus musculus P63002
Y2H
12050133
种属间
Six3 Q62233 gro Drosophila melanogaster P16371
Pull Down
12050133
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12960 SIX3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21433 Six3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27951 Six3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Six3 NCBI NCBI:6496
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z