2. Gene
  3. Six4 - sine oculis-related homeobox 4 Gene

Six4 - sine oculis-related homeobox 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AREC3; TrexBF

基因 ID: 20474 | 基因类型: protein coding

关于 Six4

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of morphogenesis of an epithelium; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including embryonic organ morphogenesis; myoblast migration; and thymus development. Located in cytoplasm and nucleus. Is expressed in several structures, including exocrine gland; nervous system; sensory organ; tongue; and urinary system. Orthologous to human SIX4 (SIX homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Six4 基因产物(3)

mRNA Protein Name
NM_001362272.2 NP_001349201.1 homeobox protein SIX4 isoform 2
NM_001409898.1 NP_001396827.1 homeobox protein SIX4 isoform 3
NM_011382.3 NP_035512.1 homeobox protein SIX4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
14966291 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15955062 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
14966291 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15955062 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12215533 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8814301 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anatomical structure development IGI
IGI: 通过遗传相互作用推断
16530750 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: 通过遗传相互作用推断
20515681 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
15788460 MGI
involved in fungiform papilla morphogenesis IMP
IMP: 通过突变表型推断
21978088 MGI
involved in generation of neurons IMP
IMP: 通过突变表型推断
16938278 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: 通过遗传相互作用推断
15788460 MGI
involved in male gonad development IMP
IMP: 通过突变表型推断
23987514 MGI
involved in male sex determination IMP
IMP: 通过突变表型推断
23987514 MGI
involved in male sex differentiation IMP
IMP: 通过突变表型推断
23987514 MGI
involved in metanephric mesenchyme development IMP
IMP: 通过突变表型推断
17300925 MGI
acts upstream of or within myoblast migration IGI
IGI: 通过遗传相互作用推断
15788460 MGI
involved in myotome development IMP
IMP: 通过突变表型推断
15788460 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15955062 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
15788460 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
16938278 MGI
involved in negative regulation of satellite cell differentiation IMP
IMP: 通过突变表型推断
20696153 MGI
involved in olfactory placode formation IMP
IMP: 通过突变表型推断
19027001 MGI
involved in pharyngeal system development IMP
IMP: 通过突变表型推断
16530750 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14966291 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15955062 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17300925 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
17300925 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15955062 MGI
involved in positive regulation of ureteric bud formation IMP
IMP: 通过突变表型推断
17300925 MGI
involved in protein localization to nucleus IDA
IDA: 通过直接分析推断
10490620 MGI
involved in regulation of branch elongation involved in ureteric bud branching IMP
IMP: 通过突变表型推断
17300925 MGI
involved in regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
19027001 MGI
acts upstream of or within regulation of gene expression IGI
IGI: 通过遗传相互作用推断
21884692 MGI
acts upstream of or within regulation of protein localization IGI
IGI: 通过遗传相互作用推断
21884692 MGI
acts upstream of or within regulation of synaptic assembly at neuromuscular junction IGI
IGI: 通过遗传相互作用推断
21884692 MGI
involved in sarcomere organization IMP
IMP: 通过突变表型推断
21884692 MGI
involved in skeletal muscle fiber differentiation IMP
IMP: 通过突变表型推断
21884692 MGI
acts upstream of or within skeletal muscle tissue development IGI
IGI: 通过遗传相互作用推断
15788460 MGI
involved in skeletal muscle tissue development IMP
IMP: 通过突变表型推断
17592144 MGI
acts upstream of or within thymus development IGI
IGI: 通过遗传相互作用推断
16530750 MGI
involved in tongue development IMP
IMP: 通过突变表型推断
21978088 MGI
involved in trigeminal ganglion development IMP
IMP: 通过突变表型推断
16938278 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9990334 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8814301 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

homeobox protein SIX4

sine oculis-related homeobox 4 homolog

skeletal muscle-specific ARE-binding protein AREC3

Six4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Six4 Q61321 Kdm6a Mus musculus O70546
Anti Bait CoIP
20300060
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12961 SIX4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21434 Six4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27952 Six4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Six4 NCBI NCBI:51804
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