EPHB2 - EPH receptor B2 Gene

中文名称：EPH 受体 B2

种属: Homo sapiens

同用名: DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; BDPLT22

基因 ID: 2048 | 基因类型: protein coding

关于 EPHB2

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,710,838-22,921,500 (from NCBI)

This gene has 7 transcripts (splice variants), 288 orthologues, 53 paralogues and is associated with 3 phenotypes. Broad expression in colon (RPKM 7.3), small intestine (RPKM 5.2) and 17 other tissues.

功能概要

该基因编码受体酪氨酸激酶跨膜糖蛋白的 Eph 受体家族成员。这些受体由 N 末端糖基化配体结合结构域、跨膜区域和细胞内激酶结构域组成。它们结合称为肝配蛋白的配体，并参与多种细胞过程，包括运动、分裂和分化。 Eph-ephrin 信号的一个显着特征是受体和配体都能够转导信号级联，从而产生双向信号。这种蛋白质属于称为 EphB 的 Eph 受体亚组。该亚组的蛋白质通过序列同源性和对膜结合 ephrin-B 配体的优先结合亲和力与该家族的其他成员区分开来。等位基因变异与前列腺癌和脑癌易感性相关。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 5 月]

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called Ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph Receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain Cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

EPHB2 基因产物(4)

mRNA	Protein	Name
NM_001309192.2	NP_001296121.1	ephrin type-B receptor 2 isoform 3 precursor
NM_001309193.2	NP_001296122.1	ephrin type-B receptor 2 isoform 4 precursor
NM_004442.7	NP_004433.2	ephrin type-B receptor 2 isoform 2 precursor
NM_017449.5	NP_059145.2	ephrin type-B receptor 2 isoform 1 precursor

EPHB2 蛋白结构

Ephrin_lbd

Ephrin_rec_like

fn3

EphA2_TM

Pkinase_Tyr

SAM_1

0
200
400
600
800
1000
1055 a.a.

蛋白主名

其他名称

ephrin type-B receptor 2

EPH-like kinase 5

重组 EPHB2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70790	EphB2 Protein, Human (HEK293, Fc)	Q6NVW1 (V19-S482)	≥95%
HY-P72999	EphB2 Protein, Human (HEK293)	P29323 (M1-L543)	≥95%
HY-P73000	EphB2 Protein, Human (sf9, His-GST)	P29323-3 (G570-V987)	≥95%
HY-P73001	EphB2 Protein, Human (HEK293, His-Fc)	P29323/NP_059145.2 (V19-L543)	≥95%
HY-P75237	EphB2 Protein, Human (HEK293, His)	P29323 (V19-L543)	≥95%

关联疾病

疾病名称

别名

Bleeding Disorder, Platelet-Type, 22

BDPLT22

Prostate Cancer/Brain Cancer Susceptibility

Pcbc	Capb
Prostate Cancer/Brain Cancer Susceptibility, Somatic

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Transitional Cell Carcinoma

Transitional Cell Neoplasm	Carcinoma, Transitional Cell
Transitional Carcinoma	Transitional Cell Tumor
Urothelial Cell Carcinoma	Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia	CFNS
Cfnd	Craniofrontonasal Dysostosis
Craniofrontonasal Dystosis	Dysplasia, Craniofrontonasal

Supratentorial Ependymoma

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-18833	ALW-II-49-7	Inhibitor	99.80%	否
HY-146375	UniPR505	Antagonist	/	否
HY-157019	UniPR1447	Antagonist	/	否
HY-RS04434	EPHB2 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	EPHB2	RGD	RGD:1564232
Bos taurus	EPHB2	VGNC	VGNC:54424
Mus musculus	EPHB2	MGD	MGI:99611
Canis familiaris	EPHB2	VGNC	VGNC:40411
Felis catus	EPHB2	VGNC	VGNC:80196
Macaca mulatta	EPHB2	VGNC	VGNC:99906
Macaca fascicularis	EPHB2	NCBI
Others	EPHB2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

EPHB2 - EPH receptor B2 Gene

关于 EPHB2

功能概要

EPHB2 基因产物(4)

EPHB2 蛋白结构

重组 EPHB2 蛋白

关联疾病

直系同源

热门区域

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EPHB2 - EPH receptor B2 Gene

关于 EPHB2

功能概要

EPHB2 基因产物(4)

EPHB2 蛋白结构

重组 EPHB2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z