2. Gene
  3. Ski - ski sarcoma viral oncogene homolog (avian) Gene

Ski - ski sarcoma viral oncogene homolog (avian) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 2310012I02Rik; 2610001A11Rik

基因 ID: 20481 | 基因类型: protein coding

关于 Ski

功能概要

Enables chromatin binding activity and histone deacetylase inhibitor activity. Acts upstream of or within several processes, including animal organ development; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription repressor complex. Is expressed in embryo; forelimb bud; and forelimb interdigital region. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ski 基因产物(2)

mRNA Protein Name
NM_001357191.1 NP_001344120.1 ski oncogene isoform 2
NM_011385.2 NP_035515.2 ski oncogene isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IGI
IGI: 通过遗传相互作用推断
19008232 MGI
enables histone deacetylase inhibitor activity IGI
IGI: 通过遗传相互作用推断
17352741 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12435627 MGI
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
10049357 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anterior/posterior axis specification IMP
IMP: 通过突变表型推断
11731796 MGI
acts upstream of or within bone morphogenesis IMP
IMP: 通过突变表型推断
9284043 MGI
acts upstream of or within camera-type eye development IMP
IMP: 通过突变表型推断
11731796 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
17003410 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
12435627 MGI
acts upstream of or within face morphogenesis IMP
IMP: 通过突变表型推断
9284043 MGI
acts upstream of fibroblast proliferation IMP
IMP: 通过突变表型推断
11781823 MGI
acts upstream of or within lens morphogenesis in camera-type eye IMP
IMP: 通过突变表型推断
17003410 MGI
acts upstream of or within myelination in peripheral nervous system IMP
IMP: 通过突变表型推断
15312649 MGI
acts upstream of or within myotube differentiation IDA
IDA: 通过直接分析推断
17352741 MGI
acts upstream of or within myotube differentiation IGI
IGI: 通过遗传相互作用推断
19008232 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
21937600 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
11781823 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
7659522 MGI
involved in negative regulation of transcription by RNA polymerase III IMP
IMP: 通过突变表型推断
10049357 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
21937600 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
9284043 MGI
acts upstream of or within nose morphogenesis IMP
IMP: 通过突变表型推断
11731796 MGI
acts upstream of or within olfactory bulb development IMP
IMP: 通过突变表型推断
11731796 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7659522 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19008232 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
17003410 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
11731796 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: 通过突变表型推断
9284043 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: 通过直接分析推断
19379700 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12435627 MGI
located in nucleus IDA
IDA: 通过直接分析推断
7823166 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
19008232 MGI
part of transcription repressor complex IDA
IDA: 通过直接分析推断
12435627 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ski oncogene

C-ski

Sloan-Kettering viral oncogene homolog

proto-oncogene c-Ski

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10158 Bosutinib 99.96% 是
HY-10158A Bosutinib hydrate Inhibitor 99.97% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13822 SKI II 99.25% 否
HY-18366A RU-SKI 43 hydrochloride Inhibitor 99.55% 否
HY-12892 SKI-178 99.29% 否
HY-162143 SKI-349 Inhibitor 99.58% 否
HY-115735 SKI-I 99.14% 否
HY-109082A Cevidoplenib dimesylate Inhibitor 98.96% 否
HY-12895 SKI V 98.95% 否
HY-18366 RU-SKI 43 Inhibitor / 否
HY-10158S Bosutinib-d8 ≥99.0% 否
HY-19325 SKI2852 Inhibitor 98.33% 否
HY-10158AR Bosutinib hydrate (Standard) Inhibitor / 否
HY-106588 Heptaplatin / 否
HY-117563 CAY10621 Inhibitor / 否
HY-161441 SIK-IN-2 Inhibitor / 否
HY-161442 SIK-IN-3 Inhibitor / 否
HY-N12455 Comosone II / 否
HY-RS12969 SKI Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-10158S1 Bosutinib-13C,d3 / 否
HY-114206 SKI-73 / 否
HY-117982 SKI2496 / 否
HY-RS18593 Ski Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25078 Ski Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W714171 Propoxycarbazone sodium / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ski NCBI NCBI:6497
Macaca fascicularis Ski NCBI NCBI:102144358
Rattus norvegicus Ski NCBI NCBI:313757
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