2. Gene
  3. Slc1a1 - solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Gene

Slc1a1 - solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: EAAC1; EAAC2; EAAT3; MEAAC1; D130048G10Rik

基因 ID: 20510 | 基因类型: protein coding

关于 Slc1a1

功能概要

Enables anion transmembrane transporter activity and identical protein binding activity. Involved in several processes, including cation transmembrane transport; learning or memory; and response to alkaloid. Acts upstream of or within several processes, including behavioral fear response; ion homeostasis; and regulation of cellular protein metabolic process. Located in several cellular components, including apical plasma membrane; endosome membrane; and membrane raft. Is integral component of plasma membrane. Is active in cytoplasm and dendrite. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Used to study dicarboxylic aminoaciduria and low tension glaucoma. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a1 基因产物(1)

mRNA Protein Name
NM_009199.3 NP_033225.1 excitatory amino acid transporter 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-glutamate transmembrane transporter activity IDA
IDA: 通过直接分析推断
11030592 MGI
enables L-glutamate transmembrane transporter activity IMP
IMP: 通过突变表型推断
14715943 MGI
enables cysteine transmembrane transporter activity IDA
IDA: 通过直接分析推断
12614333 MGI
enables glutamate:sodium symporter activity IDA
IDA: 通过直接分析推断
12119102 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15009636 MGI
enables monoatomic anion channel activity IDA
IDA: 通过直接分析推断
15471567 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16858406 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled dopamine receptor signaling pathway IMP
IMP: 通过突变表型推断
28507136 MGI
acts upstream of or within L-glutamate import across plasma membrane IDA
IDA: 通过直接分析推断
11030592 MGI
acts upstream of or within L-glutamate import across plasma membrane IMP
IMP: 通过突变表型推断
15140926 MGI
acts upstream of or within L-glutamate transmembrane transport IDA
IDA: 通过直接分析推断
15009636 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16858406 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
16858406 MGI
involved in activation of protein kinase B activity IMP
IMP: 通过突变表型推断
23827345 MGI
involved in adult behavior IMP
IMP: 通过突变表型推断
28886095 MGI
acts upstream of or within behavioral fear response IMP
IMP: 通过突变表型推断
22221107 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: 通过突变表型推断
25350110 MGI
involved in brain development IMP
IMP: 通过突变表型推断
28886095 MGI
acts upstream of or within cellular response to ammonium ion IDA
IDA: 通过直接分析推断
24412196 MGI
acts upstream of or within cellular response to ammonium ion IMP
IMP: 通过突变表型推断
24412196 MGI
acts upstream of or within cellular response to bisphenol A IDA
IDA: 通过直接分析推断
21980460 MGI
involved in cellular response to cocaine IDA
IDA: 通过直接分析推断
27208619 MGI
acts upstream of or within cellular response to mercury ion IDA
IDA: 通过直接分析推断
15635608 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: 通过突变表型推断
22732503 MGI
involved in conditioned place preference IMP
IMP: 通过突变表型推断
28049029 MGI
involved in cysteine transmembrane transport IDA
IDA: 通过直接分析推断
30840898 MGI
involved in cytokine production IMP
IMP: 通过突变表型推断
28886095 MGI
involved in cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
28886095 MGI
involved in dopamine metabolic process IMP
IMP: 通过突变表型推断
28507136 MGI
acts upstream of or within establishment of protein localization IMP
IMP: 通过突变表型推断
19923291 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
28507136 MGI
involved in glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
29229708 MGI
involved in glutathione biosynthetic process IDA
IDA: 通过直接分析推断
12614333 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: 通过突变表型推断
18799673 MGI
involved in glutathione metabolic process IMP
IMP: 通过突变表型推断
28886095 MGI
involved in grooming behavior IMP
IMP: 通过突变表型推断
28507136 MGI
acts upstream of or within heart contraction IMP
IMP: 通过突变表型推断
23361868 MGI
acts upstream of or within intracellular glutamate homeostasis IMP
IMP: 通过突变表型推断
19923291 MGI
acts upstream of or within intracellular zinc ion homeostasis IMP
IMP: 通过突变表型推断
22575539 MGI
involved in intracellular zinc ion homeostasis IMP
IMP: 通过突变表型推断
21084597 MGI
acts upstream of or within learning or memory IMP
IMP: 通过突变表型推断
22221107 MGI
involved in locomotory behavior IMP
IMP: 通过突变表型推断
28507136 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: 通过突变表型推断
19923291 MGI
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
29229708 MGI
acts upstream of or within maintenance of blood-brain barrier IMP
IMP: 通过突变表型推断
25350110 MGI
involved in memory IMP
IMP: 通过突变表型推断
28886095 MGI
involved in motor behavior IMP
IMP: 通过突变表型推断
28886095 MGI
acts upstream of or within motor neuron apoptotic process IDA
IDA: 通过直接分析推断
16858406 MGI
acts upstream of or within motor neuron apoptotic process IMP
IMP: 通过突变表型推断
16858406 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
29720605 MGI
involved in neurogenesis IMP
IMP: 通过突变表型推断
29720605 MGI
involved in neuron apoptotic process IMP
IMP: 通过突变表型推断
27040821 MGI
acts upstream of or within neurotransmitter receptor transport to plasma membrane IMP
IMP: 通过突变表型推断
24412196 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
24412196 MGI
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
23361868 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
19923291 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
19923291 MGI
involved in regulation of heart rate IMP
IMP: 通过突变表型推断
23361868 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24412196 MGI
acts upstream of or within regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
24412196 MGI
involved in response to amphetamine IMP
IMP: 通过突变表型推断
28507136 MGI
acts upstream of or within response to anesthetic IMP
IMP: 通过突变表型推断
22221107 MGI
involved in response to anesthetic IMP
IMP: 通过突变表型推断
23827345 MGI
acts upstream of or within response to axon injury IDA
IDA: 通过直接分析推断
16858406 MGI
acts upstream of or within response to axon injury IMP
IMP: 通过突变表型推断
16858406 MGI
involved in response to axon injury IMP
IMP: 通过突变表型推断
23827345 MGI
acts upstream of or within response to decreased oxygen levels IMP
IMP: 通过突变表型推断
25350110 MGI
involved in response to decreased oxygen levels IMP
IMP: 通过突变表型推断
29720605 MGI
involved in response to morphine IDA
IDA: 通过直接分析推断
28049029 MGI
involved in response to morphine IMP
IMP: 通过突变表型推断
28049029 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
20875840 MGI
involved in retina development in camera-type eye IMP
IMP: 通过突变表型推断
28703795 MGI
acts upstream of or within retina layer formation IMP
IMP: 通过突变表型推断
19766171 MGI
involved in retina layer formation IMP
IMP: 通过突变表型推断
29677370 MGI
acts upstream of or within righting reflex IMP
IMP: 通过突变表型推断
20875840 MGI
involved in superoxide metabolic process IMP
IMP: 通过突变表型推断
27040821 MGI
involved in synapse organization IMP
IMP: 通过突变表型推断
28886095 MGI
involved in zinc ion transmembrane transport IMP
IMP: 通过突变表型推断
27040821 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
19923291 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
19923291 MGI
is active in apical plasma membrane IDA
IDA: 通过直接分析推断
26739563 MGI
is active in cell surface IDA
IDA: 通过直接分析推断
15009636 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
20357106 MGI
is active in dendrite IDA
IDA: 通过直接分析推断
22539860 MGI
located in early endosome membrane IDA
IDA: 通过直接分析推断
30840898 MGI
located in membrane IDA
IDA: 通过直接分析推断
29350434 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
15187084 MGI
is active in neuronal cell body IDA
IDA: 通过直接分析推断
22539860 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
15471567 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
15009636 MGI
is active in plasma membrane IPI
IPI: 通过物理相互作用推断
18799673 MGI
is active in recycling endosome IDA
IDA: 通过直接分析推断
20357106 MGI
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
30840898 MGI
is active in synapse IDA
IDA: 通过直接分析推断
12710013 MGI
located in vesicle IDA
IDA: 通过直接分析推断
19364521 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

excitatory amino acid transporter 3

excitatory amino acid carrier 2

excitatory amino-acid carrier 1

glutamate transporter mEAAC2

sodium-dependent glutamate/aspartate transporter 3

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13050 SLC1A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21933 Slc1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc1a1 NCBI NCBI:6505
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