2. Gene
  3. Slc4a1 - solute carrier family 4 (anion exchanger), member 1 Gene

Slc4a1 - solute carrier family 4 (anion exchanger), member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ae1; CD233; Empb3; l11Jus51

基因 ID: 20533 | 基因类型: protein coding

关于 Slc4a1

功能概要

Enables anion transmembrane transporter activity; ankyrin binding activity; and Hemoglobin binding activity. Involved in chloride transport. Acts upstream of or within several processes, including bicarbonate transport; erythrocyte development; and negative regulation of glycolytic process through fructose-6-phosphate. Located in basolateral plasma membrane; cortical cytoskeleton; and cytoplasmic side of plasma membrane. Is expressed in several structures, including blood; blood vessel; liver; lung; and metanephros. Used to study hereditary spherocytosis type 4 and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a1 基因产物(1)

mRNA Protein Name
NM_011403.2 NP_035533.1 band 3 anion transport protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ankyrin binding IPI
IPI: 通过物理相互作用推断
17715300 MGI
enables bicarbonate transmembrane transporter activity IDA
IDA: 通过直接分析推断
23878365 MGI
enables chloride transmembrane transporter activity IDA
IDA: 通过直接分析推断
17690150 MGI
enables chloride:bicarbonate antiporter activity IMP
IMP: 通过突变表型推断
17409310 MGI
enables hemoglobin binding IDA
IDA: 通过直接分析推断
22452706 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11591653 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bicarbonate transport IDA
IDA: 通过直接分析推断
23878365 MGI
acts upstream of or within blood coagulation IMP
IMP: 通过突变表型推断
9716609 MGI
involved in chloride transport IDA
IDA: 通过直接分析推断
17690150 MGI
acts upstream of or within erythrocyte development IMP
IMP: 通过突变表型推断
17715300 MGI
acts upstream of or within negative regulation of glycolytic process through fructose-6-phosphate IMP
IMP: 通过突变表型推断
18698006 MGI
acts upstream of or within negative regulation of oxidoreductase activity IMP
IMP: 通过突变表型推断
18698006 MGI
acts upstream of or within negative regulation of urine volume IMP
IMP: 通过突变表型推断
17409310 MGI
acts upstream of or within pH elevation IMP
IMP: 通过突变表型推断
17409310 MGI
acts upstream of or within plasma membrane phospholipid scrambling IMP
IMP: 通过突变表型推断
9716609 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: 通过突变表型推断
18698006 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
12388412 MGI
located in cortical cytoskeleton IDA
IDA: 通过直接分析推断
18723693 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
17715300 MGI
located in membrane IDA
IDA: 通过直接分析推断
17690150 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
23878365 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

band 3 anion transport protein

AE 1

MEB3

anion exchange protein 1

anion exchanger 1

erythrocyte membrane protein band 3

solute carrier family 4 member 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13265 SLC4A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20193 Slc4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26698 Slc4a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc4a1 NCBI NCBI:6521
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