2. Gene
  3. Sod2 - superoxide dismutase 2, mitochondrial Gene

Sod2 - superoxide dismutase 2, mitochondrial Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MnSOD; Sod-2

基因 ID: 20656 | 基因类型: protein coding

关于 Sod2

功能概要

Enables superoxide dismutase activity. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of cellular biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Canavan disease; Leigh disease; amyotrophic lateral sclerosis type 1; congestive heart failure; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sod2 基因产物(1)

mRNA Protein Name
NM_013671.3 NP_038699.2 superoxide dismutase [Mn], mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables oxidoreductase activity IMP
IMP: 通过突变表型推断
15205258 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21909133 MGI
enables superoxide dismutase activity IDA
IDA: 通过直接分析推断
7333654 MGI
enables superoxide dismutase activity IMP
IMP: 通过突变表型推断
12176043 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
16873728 MGI
acts upstream of or within apoptotic mitochondrial changes IMP
IMP: 通过突变表型推断
11226230 MGI
acts upstream of or within detection of oxygen IMP
IMP: 通过突变表型推断
11156968 MGI
acts upstream of or within erythrophore differentiation IMP
IMP: 通过突变表型推断
15205258 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: 通过突变表型推断
10049502 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
7493016 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
8790408 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
15642323 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: 通过突变表型推断
15642323 MGI
acts upstream of or within liver development IMP
IMP: 通过突变表型推断
17367743 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
8790408 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
8790408 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
15205258 MGI
acts upstream of or within negative regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
16219542 MGI
acts upstream of or within negative regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
18218638 MGI
acts upstream of or within neuron development IMP
IMP: 通过突变表型推断
8790408 MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
15637112 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
7493016 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: 通过突变表型推断
17023572 MGI
acts upstream of or within regulation of catalytic activity IMP
IMP: 通过突变表型推断
9927656 MGI
acts upstream of or within regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
17367743 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17670746 MGI
acts upstream of or within release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
10212301 MGI
acts upstream of or within removal of superoxide radicals IMP
IMP: 通过突变表型推断
16873728 MGI
acts upstream of or within respiratory electron transport chain IMP
IMP: 通过突变表型推断
11226230 MGI
acts upstream of or within response to activity IMP
IMP: 通过突变表型推断
15781740 MGI
acts upstream of or within response to axon injury IMP
IMP: 通过突变表型推断
16677818 MGI
acts upstream of or within response to gamma radiation IGI
IGI: 通过遗传相互作用推断
15182862 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: 通过突变表型推断
15642323 MGI
acts upstream of or within response to hyperoxia IMP
IMP: 通过突变表型推断
11796207 MGI
acts upstream of or within response to oxidative stress IGI
IGI: 通过遗传相互作用推断
15182862 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
15182862 MGI
acts upstream of or within response to reactive oxygen species IMP
IMP: 通过突变表型推断
9462746 MGI
acts upstream of or within response to superoxide IMP
IMP: 通过突变表型推断
11156968 MGI
NOT acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
16843623 MGI
acts upstream of or within superoxide anion generation IMP
IMP: 通过突变表型推断
10212301 MGI
acts upstream of or within superoxide metabolic process IMP
IMP: 通过突变表型推断
10049502 MGI
acts upstream of or within vasodilation IMP
IMP: 通过突变表型推断
15637112 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
11583975 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

superoxide dismutase [Mn], mitochondrial

manganese SOD

manganese superoxide dismutase

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-175352 Nurr1 Agonist 14 / Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134476 NF-κΒ activator 1 Activator 99.59% 否
HY-134477 NF-κΒ activator 2 Activator 99.76% 否
HY-W014940 Ethylene glycol dimethacrylate 99.52% 否
HY-158162 SIRT3 activator 1 Activator 98.14% 否
HY-RS13560 SOD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16939 Sod2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23382 Sod2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sod2 NCBI NCBI:6648
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