Sox10 - SRY (sex determining region Y)-box 10 Gene

种属: Mus musculus

同用名: gt; Dom; Sox21

关于 Sox10

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; neural crest cell migration; and neurogenesis. Acts upstream of or within several processes, including lacrimal gland development; melanocyte differentiation; and nervous system development. Located in cytoplasm and nucleus. Is extrinsic component of mitochondrial outer membrane. Is expressed in several structures, including alimentary system; genitourinary system; inner ear; mesenchyme derived from neural crest; and nervous system. Used to study Kallmann syndrome; PCWH syndrome; and Waardenburg syndrome type 4C. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2022]