2. Gene
  3. Sphk1 - sphingosine kinase 1 Gene

Sphk1 - sphingosine kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：鞘氨醇激酶 1

种属: Mus musculus

同用名: Sk1; Spk1; 1110006G24Rik

基因 ID: 20698 | 基因类型: protein coding

关于 Sphk1

Chromosome 11: 116,421,751-116,427,501 forward strand.GRCm39:CM001004.3

This gene has 17 transcripts (splice variants), 277 orthologues, 4 paralogues and is associated with 21 phenotypes. Broad expression in lung adult (RPKM 8.3), duodenum adult (RPKM 6.9) and 25 other tissues.

功能概要

该基因编码一种激酶，可将鞘氨醇磷酸化为鞘氨醇-1-磷酸，参与细胞分化、运动和细胞凋亡。编码的蛋白质在维持细胞内 1-磷酸鞘氨醇水平方面发挥作用。可变剪接导致多个转录本变体。 [RefSeq 提供，2010 年 2 月]

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and Apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Sphk1 基因产物(10)

mRNA Protein Name
NM_001172475.1 NP_001165946.1 sphingosine kinase 1 isoform 3
NM_001372488.1 NP_001359417.1 sphingosine kinase 1 isoform 3
NM_001372485.1 NP_001359414.1 sphingosine kinase 1 isoform 4
NM_025367.7 NP_079643.2 sphingosine kinase 1 isoform 2
NM_001372489.1 NP_001359418.1 sphingosine kinase 1 isoform 3
NM_001172472.2 NP_001165943.1 sphingosine kinase 1 isoform 2
NM_001372487.1 NP_001359416.1 sphingosine kinase 1 isoform 4
NM_001372486.1 NP_001359415.1 sphingosine kinase 1 isoform 2
NM_001372484.1 NP_001359413.1 sphingosine kinase 1 isoform 2
NM_001172473.1 NP_001165944.1 sphingosine kinase 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-erythro-sphingosine kinase activity IDA
IDA: 通过直接分析推断
9726979 MGI
enables acetyltransferase activity IMP
IMP: 通过突变表型推断
29662056 MGI
enables sphingosine kinase activity IDA
IDA: 通过直接分析推断
25417698 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA biosynthetic process IMP
IMP: 通过突变表型推断
23651497 MGI
acts upstream of or within blood vessel development IGI
IGI: 通过遗传相互作用推断
16314531 MGI
acts upstream of or within brain development IGI
IGI: 通过遗传相互作用推断
16314531 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
16314531 MGI
acts upstream of or within cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
23651497 MGI
involved in cellular response to vascular endothelial growth factor stimulus IDA
IDA: 通过直接分析推断
25417698 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
18305483 MGI
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
16118219 MGI
involved in negative regulation of ceramide biosynthetic process IMP
IMP: 通过突变表型推断
16118219 MGI
involved in phosphorylation IDA
IDA: 通过直接分析推断
9726979 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
16314531 MGI
acts upstream of or within positive regulation of mitotic nuclear division IGI
IGI: 通过遗传相互作用推断
23651497 MGI
involved in protein acetylation IMP
IMP: 通过突变表型推断
29662056 MGI
involved in regulation of endocytosis IMP
IMP: 通过突变表型推断
27806293 MGI
involved in regulation of endosomal vesicle fusion IMP
IMP: 通过突变表型推断
27806293 MGI
acts upstream of or within regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
18305483 MGI
involved in regulation of microglial cell activation IMP
IMP: 通过突变表型推断
29662056 MGI
involved in regulation of neuroinflammatory response IMP
IMP: 通过突变表型推断
29662056 MGI
involved in regulation of phagocytosis IMP
IMP: 通过突变表型推断
29662056 MGI
acts upstream of or within sphingolipid mediated signaling pathway IDA
IDA: 通过直接分析推断
23651497 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16118219 MGI
located in cytoplasm IMP
IMP: 通过突变表型推断
27806293 MGI
located in endocytic vesicle IDA
IDA: 通过直接分析推断
27806293 MGI
located in nucleus IDA
IDA: 通过直接分析推断
29662056 MGI
located in presynapse IDA
IDA: 通过直接分析推断
24929359 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sphk1 蛋白结构

PLN02958

PLN02958: cl29912 (10 - 343)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
蛋白主名 其他名称

sphingosine kinase 1

acetyltransferase SPHK1

相关产品

Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15425 PF-543 Inhibitor 99.85% 否
HY-15425A PF-543 Citrate Inhibitor 99.47% 否
HY-124042 K6PC-5 Activator 99.27% 否
HY-101572 MHP Activator 98.57% 否
HY-12892 SKI-178 Inhibitor 99.29% 否
HY-119016 SK1-I Inhibitor 98.83% 否
HY-101805 SK1-IN-1 Inhibitor 98.10% 否
HY-147282 Amgen-23 Inhibitor 98.11% 否
HY-148707 SphK1&2-IN-1 Inhibitor 99.33% 否
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% 否
HY-15425B PF-543 hydrochloride Inhibitor / 否
HY-150615 SphK1-IN-2 Inhibitor / 否
HY-117563 CAY10621 Inhibitor / 否
HY-120268 SLM6031434 Inhibitor / 否
HY-120152 SLP7111228 Inhibitor / 否
HY-143296 SphK1-IN-1 Inhibitor / 否
HY-148262 SphK1-IN-3 Inhibitor / 否
HY-12900 RB-005 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sphk1 NCBI NCBI:8877
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