2. Gene
  3. Stat4 - signal transducer and activator of transcription 4 Gene

Stat4 - signal transducer and activator of transcription 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 20849 | 基因类型: protein coding

关于 Stat4

功能概要

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Stat4 基因产物(2)

mRNA Protein Name
NM_001308266.1 NP_001295195.1 signal transducer and activator of transcription 4
NM_011487.5 NP_035617.1 signal transducer and activator of transcription 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12213961 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
23772023 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12372421 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18234692 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11894097 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
11894097 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: 通过突变表型推断
26880577 MGI
acts upstream of or within leukocyte proliferation IDA
IDA: 通过直接分析推断
12213961 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
22851706 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19666510 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23772023 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
11489994 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12213961 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

signal transducer and activator of transcription 4

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-109854A (R)-Lisofylline Inhibitor 99.99% Phase 2
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-173236 STAT4-IN-1 Inhibitor 99.17% 否
HY-161464 Chlopynostat 98.36% 否
HY-173357 TYD-68 99.54% 否
HY-169360 SD-436 Degrader 98.27% 否
HY-RS13891 STAT4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-172946 SD-2301 Degrader / 否
HY-RS17148 Stat4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23597 Stat4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stat4 NCBI NCBI:6775
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