2. Gene
  3. Wfs1 - wolframin ER transmembrane glycoprotein Gene

Wfs1 - wolframin ER transmembrane glycoprotein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: wolframin

基因 ID: 22393 | 基因类型: protein coding

关于 Wfs1

功能概要

Enables ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER Transmembrane Glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Wfs1 基因产物(1)

mRNA Protein Name
NM_011716.2 NP_035846.1 wolframin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IDA
IDA: 通过直接分析推断
17947299 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IMP
IMP: 通过突变表型推断
20160352 MGI
involved in endoplasmic reticulum unfolded protein response IMP
IMP: 通过突变表型推断
16571599 MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
16571599 MGI
involved in negative regulation of translation IMP
IMP: 通过突变表型推断
19911006 MGI
involved in negative regulation of type B pancreatic cell apoptotic process IMP
IMP: 通过突变表型推断
16087305 MGI
involved in positive regulation of ERAD pathway IMP
IMP: 通过突变表型推断
19911006 MGI
involved in positive regulation of growth IMP
IMP: 通过突变表型推断
19293327 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
20160352 MGI
involved in protein stabilization IMP
IMP: 通过突变表型推断
20160352 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
15994758 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16087305 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

wolframin

Wolfram syndrome 1 homolog

Wolfram syndrome 1 protein homolog

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137605 WSF1-IN-1 Inhibitor 99.91% 否
HY-RS15813 WFS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18644 Wfs1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25129 Wfs1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Wfs1 NCBI NCBI:7466
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