2. Gene
  3. Wrn - Werner syndrome RecQ like helicase Gene

Wrn - Werner syndrome RecQ like helicase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 22427 | 基因类型: protein coding

关于 Wrn

功能概要

Enables 3'-5' exonuclease activity. Involved in G-quadruplex DNA unwinding. Acts upstream of or within several processes, including multicellular organism aging; regulation of growth rate; and replicative senescence. Located in chromosome, telomeric region; nucleoplasm; and replication fork. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]

Wrn 基因产物(2)

mRNA Protein Name
NM_001122822.1 NP_001116294.1 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
NM_011721.4 NP_035851.3 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5' exonuclease activity IDA
IDA: 通过直接分析推断
10871373 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11301316 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA metabolic process IMP
IMP: 通过突变表型推断
11756244 MGI
involved in DNA replication IGI
IGI: 通过遗传相互作用推断
26195664 MGI
acts upstream of or within DNA replication IMP
IMP: 通过突变表型推断
9789047 MGI
involved in DNA replication IMP
IMP: 通过突变表型推断
26195664 MGI
involved in G-quadruplex DNA unwinding IGI
IGI: 通过遗传相互作用推断
26195664 MGI
involved in G-quadruplex DNA unwinding IMP
IMP: 通过突变表型推断
26195664 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: 通过遗传相互作用推断
15235603 MGI
acts upstream of or within regulation of growth rate IMP
IMP: 通过突变表型推断
12707040 MGI
acts upstream of or within replicative senescence IMP
IMP: 通过突变表型推断
10757812 MGI
acts upstream of or within telomere maintenance IGI
IGI: 通过遗传相互作用推断
15235603 MGI
acts upstream of or within telomere maintenance IMP
IMP: 通过突变表型推断
12707040 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, telomeric region IMP
IMP: 通过突变表型推断
26195664 MGI
NOT located in nucleolus IDA
IDA: 通过直接分析推断
11420665 MGI
located in nucleoplasm IDA
IDA: 通过直接分析推断
11420665 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9789047 MGI
located in replication fork IMP
IMP: 通过突变表型推断
26195664 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Werner syndrome ATP-dependent helicase homolog

Werner syndrome homolog

Werner syndrome protein homolog

exonuclease WRN

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-148699 HRO761 Inhibitor 99.58% Phase 1
HY-158116 VVD-214 Inhibitor 99.76% Phase 1
Pre-clinical Phase
生物活性分子 (38)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12342 ML216 Inhibitor 99.89% 否
HY-110185 NSC 617145 Inhibitor 99.18% 否
HY-148740 Werner syndrome RecQ helicase-IN-3 Inhibitor 99.94% 否
HY-149887 H3B-968 98.22% 否
HY-162471 GSK_WRN3 Inhibitor 98.54% 否
HY-169422 GSK4418959 Inhibitor 98.72% 否
HY-128712 NCGC00029283 Inhibitor 98.88% 否
HY-156579 WRN inhibitor 3 Inhibitor 99.54% 否
HY-156580 WRN inhibitor 4 Inhibitor 99.40% 否
HY-156581 WRN inhibitor 5 Inhibitor 98.12% 否
HY-163942 GSK_WRN4 Inhibitor 98.85% 否
HY-160859 WRN inhibitor 8 Inhibitor 98.07% 否
HY-148741 Werner syndrome RecQ helicase-IN-4 Inhibitor 98.13% 否
HY-153692 WRN inhibitor 1 Inhibitor 98.05% 否
HY-163941 GSK_WRN2 95.95% 否
HY-148700 Werner syndrome RecQ helicase-IN-2 Inhibitor 99.32% 否
HY-153973 WRN inhibitor 2 / 否
HY-158025 Anticancer agent 198 Inhibitor / 否
HY-175750 MOMA-341 Inhibitor / 否
HY-153692A (R)-WRN inhibitor 1 / 否
HY-157954 WRN inhibitor 6 / 否
HY-161386 WRN inhibitor 7 / 否
HY-163797 WRN inhibitor 10 Inhibitor / 否
HY-164852 WRN inhibitor 13 / 否
HY-168583 WRN inhibitor 11 Inhibitor / 否
HY-168592 WRN inhibitor 12 Inhibitor / 否
HY-168933 KWR095 Inhibitor / 否
HY-168934 KWR137 Inhibitor / 否
HY-169414 WRN inhibitor 15 / 否
HY-169422A GSK4418959 (enantiomer) / 否
HY-169423 WRN inhibitor 17 Inhibitor / 否
HY-169424 WRN inhibitor 18 Inhibitor / 否
HY-169928 WRN inhibitor 14 Inhibitor / 否
HY-174217 WRN-IN-19 Inhibitor / 否
HY-176727 WRN inhibitor 19 Inhibitor / 否
HY-RS15847 WRN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16538 Wrn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22970 Wrn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Wrn NCBI NCBI:7486
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