2. Gene
  3. FGF11 - fibroblast growth factor 11 Gene

FGF11 - fibroblast growth factor 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：成纤维细胞生长因子 11

种属: Homo sapiens

同用名: FHF3; FHF-3; FGF-11

基因 ID: 2256 | 基因类型: protein coding

关于 FGF11

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,438,298-7,444,937 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 277 orthologues and 21 paralogues. Broad expression in adrenal (RPKM 9.9), skin (RPKM 7.0) and 14 other tissues.

功能概要

该基因编码的蛋白质是成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。该基因的功能尚未确定。小鼠同系物的表达模式暗示其在神经系统发育中的作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 1 月]

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

FGF11 基因产物(2)

mRNA Protein Name
NM_001303460.2 NP_001290389.1 fibroblast growth factor 11 isoform 2
NM_004112.4 NP_004103.1 fibroblast growth factor 11 isoform 1

FGF11 蛋白结构

FGF

FGF: Fibroblast growth factor (72 - 197)

  • 0
  • 100
  • 200
  • 225 a.a.
蛋白主名 其他名称

fibroblast growth factor 11

fibroblast growth factor homologous factor 3

重组 FGF11 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700054AF Animal-Free FGF-11 isoform 1 Protein, Human (His) Q92914 (M1-P225) ≥95%
HY-P700055AF Animal-Free FGF-11 isoform 2 Protein, Human (His) NP_001290389.1 (M1-P166) ≥95%

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 27

Spinocerebellar Ataxia Type 27

SCA27

Cerebellar Ataxia Autosomal Dominant Fgf14-Related

Vestibulocerebellar Disorder With Predominant Ocular Signs

Cerebellar Ataxia, Autosomal Dominant, Fgf14-Related

Nystagmus 4, Congenital, Autosomal Dominant, Formerly

Nys4, Formerly

Ataxia, Spinocerebellar, Type 27
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04888 FGF11 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FGF11 VGNC VGNC:104600
Bos taurus FGF11 VGNC VGNC:28971
Canis familiaris FGF11 VGNC VGNC:40840
Rattus norvegicus FGF11 RGD RGD:620162
Mus musculus FGF11 MGD MGI:109167
Felis catus FGF11 VGNC VGNC:62245
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