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  3. Twnk - twinkle mtDNA helicase Gene

Twnk - twinkle mtDNA helicase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PEO; Peo1; Twinl; D19Ertd626e

基因 ID: 226153 | 基因类型: protein coding

关于 Twnk

功能概要

Enables DNA helicase activity. Involved in mitochondrial DNA replication. Acts upstream of or within DNA unwinding involved in DNA replication. Located in mitochondrion. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase). [provided by Alliance of Genome Resources, Apr 2022]

Twnk 基因产物(3)

mRNA Protein Name
NM_001348254.1 NP_001335183.1 twinkle mtDNA helicase isoform 3
NM_001348259.1 NP_001335188.1 twinkle mtDNA helicase isoform 2
NM_153796.4 NP_722491.2 twinkle mtDNA helicase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA helicase activity IDA
IDA: 通过直接分析推断
11431692 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA unwinding involved in DNA replication IDA
IDA: 通过直接分析推断
11431692 MGI
involved in mitochondrial DNA replication IMP
IMP: 通过突变表型推断
18971204 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
11431692 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

twinkle mtDNA helicase

T7 gp4-like protein with intramitochondrial nucleoid localization

progressive external ophthalmoplegia 1 protein homolog

putative T7-like mitochodrial DNA helicase twinky

twinkle protein, mitochondrial

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15283 TWNK Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20832 Twnk Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27346 Twnk Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Twnk NCBI NCBI:56652
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