UBR2 - ubiquitin protein ligase E3 component n-recognin 2 Gene

中文名称：泛素蛋白连接酶 E3 组分 n-识别素 2

种属: Homo sapiens

同用名: C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3

基因 ID: 23304 | 基因类型: protein coding

关于 UBR2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,564,029-42,693,505 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.8), spleen (RPKM 6.8) and 25 other tissues.

功能概要

该基因编码 N 末端规则蛋白水解途径的 E3 泛素连接酶，该途径靶向具有不稳定 N 末端残基的蛋白质，用于多聚泛素化和蛋白酶体介导的降解。可变剪接导致多个转录变体。[RefSeq 提供，2010 年 5 月]

This gene encodes an E3 ubiquitin Ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UBR2 基因产物(3)

mRNA	Protein	Name
NM_001184801.2	NP_001171730.1	E3 ubiquitin-protein ligase UBR2 isoform 2
NM_001363705.2	NP_001350634.1	E3 ubiquitin-protein ligase UBR2 isoform 3
NM_015255.3	NP_056070.1	E3 ubiquitin-protein ligase UBR2 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables L-leucine binding	IDA IDA: 通过直接分析推断	20298436	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22190034	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	15548684	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to L-leucine	IDA IDA: 通过直接分析推断	20298436	GOA
involved in negative regulation of TOR signaling	IMP IMP: 通过突变表型推断	20298436	GOA
involved in positive regulation of T cell receptor signaling pathway	IDA IDA: 通过直接分析推断	38225265	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	15548684	GOA
involved in protein K63-linked ubiquitination	IDA IDA: 通过直接分析推断	38225265	GOA
involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway	IDA IDA: 通过直接分析推断	20835242	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBR2 蛋白结构

zf-UBR

ClpS

0
300
600
900
1200
1500
1755 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase UBR2

RING-type E3 ubiquitin transferase UBR2

UBR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	UBR2	Q8IWV8	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Johanson-Blizzard Syndrome

JBS	Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness
Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness	Johanson Blizzard Syndrome

Oligospermia

Retinitis Pigmentosa 61

RP61	Retinitis Pigmentosa, Type 61

Night Blindness, Congenital Stationary, Type 1d

Congenital Stationary Night Blindness 1d	CSNB1D
Csnb, Complete, Autosomal Recessive	Night Blindness, Congenital Stationary , 1d, Autosomal Recessive
Congenital Stationary Night Blindness 1d Autosomal Recessive	Night Blindness, Congenital Stationary, 1d
Complete Autosomal Recessive Csnb	Blindness, Night, Stationary, Congenital, Type 1d

Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15387	UBR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	UBR2	VGNC	VGNC:79318
Rattus norvegicus	UBR2	RGD	RGD:1593237
Canis familiaris	UBR2	VGNC	VGNC:48090
Felis catus	UBR2	VGNC	VGNC:66785
Bos taurus	UBR2	VGNC	VGNC:36617
Mus musculus	UBR2	MGD	MGI:1861099

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UBR2 - ubiquitin protein ligase E3 component n-recognin 2 Gene

关于 UBR2

功能概要

UBR2 基因产物(3)

UBR2 蛋白结构

UBR2 蛋白互作信息

关联疾病

直系同源

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UBR2 - ubiquitin protein ligase E3 component n-recognin 2 Gene

关于 UBR2

功能概要

UBR2 基因产物(3)

UBR2 蛋白结构

UBR2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z