1. Gene
  2. ANGPTL2 - angiopoietin like 2 Gene

ANGPTL2 - angiopoietin like 2 Gene

中文名称:血管生成素 2

种属: Homo sapiens

同用名: ARP2; HARP

基因 ID: 23452 | 基因类型: protein coding

关于 ANGPTL2

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:127,087,348-127,122,635 (from NCBI)

This gene has 4 transcripts (splice variants), 128 orthologues and 25 paralogues. Broad expression in fat (RPKM 35.2), gall bladder (RPKM 19.9) and 22 other tissues.

功能概要

血管生成素是血管内皮生长因子家族的成员,并且是唯一已知的主要对血管内皮具有特异性的生长因子。 Angiopoietin-1、angiopoietin-2 和 Angiopoietin-4 参与血管的形成。 ANGPTL2 蛋白是一种与血管生成素同源的分泌型糖蛋白,可能通过自分泌或旁分泌作用对内皮细胞发挥作用。[RefSeq 提供,2008 年 7 月]

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and Angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the Angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]

ANGPTL2 基因产物(1)

mRNA Protein Name
NM_012098.3 NP_036230.1 angiopoietin-related protein 2 precursor

ANGPTL2 蛋白结构

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (276 - 487)

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  • 493 a.a.
蛋白主名 其他名称

angiopoietin-related protein 2

angiopoietin-like protein 2

重组 ANGPTL2 蛋白

关联疾病

疾病名称 别名
Myositis Ossificans

Myisitis Ossificans

Ossification - Muscle

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ANGPTL2 MGD MGI:1347002
Macaca mulatta ANGPTL2 VGNC VGNC:69814
Canis familiaris ANGPTL2 VGNC VGNC:37858
Bos taurus ANGPTL2 VGNC VGNC:25891
Rattus norvegicus ANGPTL2 RGD RGD:620004
Felis catus ANGPTL2 VGNC VGNC:67567
Others ANGPTL2 NCBI