1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Angiopoietins
  4. Angiopoietin Like 2
  5. ANGPTL2/Angiopoietin-like 2 蛋白, Human (His-SUMO)

ANGPTL2/Angiopoietin-like 2 蛋白, Human (His-SUMO)

目录号: HY-P71652
产品使用指南

ANGPTL2/血管生成素样 2 蛋白占据中心地位,因为它通过自分泌和旁分泌双重机制诱导内皮细胞出芽。这种能力强调了它在血管生成中的关键作用,其中平衡的信号事件控制新血管的形成。ANGPTL2/Angiopoietin-like 2 蛋白, Human (His-SUMO) 是重组的 ANGPTL2/血管生成素样 2 蛋白,由 E. coli 表达,带有 N-His, N-SUMO 标签。ANGPTL2/Angiopoietin-like 2 蛋白, Human (His-SUMO) 全长 471 个氨基酸,分子量约为 ~70.8 kDa。

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描述

ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms. This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels. ANGPTL2/Angiopoietin-like 2 Protein, Human (His-SUMO) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of ANGPTL2/Angiopoietin-like 2 Protein, Human (His-SUMO) is 471 a.a., with molecular weight of ~70.8 kDa.

研究背景

ANGPTL2/血管生成素样 2 蛋白占据中心舞台,因为它通过自分泌和旁分泌作用的双重机制诱导出芽,对内皮细胞产生影响。该蛋白质促进发芽的能力强调了它在血管生成过程中的关键作用,在血管生成过程中,信号事件的复杂平衡控制着新血管的形成。通过作为自分泌和旁分泌因子,ANGPTL2 在调节内皮细胞行为中发挥着至关重要的作用,有助于血管生成所必需的动态和协调反应。这种多方面的作用使 ANGPTL2 成为协调血管萌芽的复杂调节网络中的关键参与者,突显了其在组织血管化的复杂过程中的重要性。

种属

Human

表达系统

E. coli

标签

N-His;N-SUMO

蛋白编号

Q9UKU9 (23Q-493H)

基因 ID
蛋白结构
N-term
6*His-SUMO
ANGPTL2 (23Q-493H)
Accession # Q9UKU9
C-term
同用名
Angiopoietin like 2; Angiopoietin related protein 2 ; Angiopoietin-like protein 2; Angiopoietin-related protein 2; HARP; MGC8889; UNQ170/PRO196
氨基酸序列

QEDGFEGTEEGSPREFIYLNRYKRAGESQDKCTYTFIVPQQRVTGAICVNSKEPEVLLENRVHKQELELLNNELLKQKRQIETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKDLEHKYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQALEDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH

分子量

Approximately 70.8 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

ANGPTL2/Angiopoietin-like 2 Protein, Human (His-SUMO) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ANGPTL2/Angiopoietin-like 2 Protein, Human (His-SUMO)
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HY-P71652
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