PES1 - pescadillo ribosomal biogenesis factor 1 Gene

中文名称：pescadillo 核糖体生物发生因子 1

种属: Homo sapiens

同用名: PES; NOP7

基因 ID: 23481 | 基因类型: protein coding

关于 PES1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,576,625-30,607,013 (from NCBI)

This gene has 13 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 9.0), ovary (RPKM 7.8) and 25 other tissues.

功能概要

该基因编码的核蛋白含有乳腺癌相关基因 1 (BRCA1) C 端相互作用结构域。编码的蛋白质与 BOP1 和 WDR12 相互作用形成 PeBoW 复合物，该复合物通过前 rRNA 加工和 60S 核糖体亚基成熟在细胞增殖中起关键作用。该基因的表达可能在乳腺癌增殖和致瘤性中发挥重要作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。该基因的假基因位于 4 号染色体的长臂和 9 号染色体的短臂上。[RefSeq 提供，2011 年 8 月]

This gene encodes a nuclear protein that contains a breast Cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast Cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

PES1 基因产物(4)

mRNA	Protein	Name
NM_001243225.2	NP_001230154.1	pescadillo homolog isoform 2
NM_001282327.1	NP_001269256.1	pescadillo homolog isoform 3
NM_001282328.1	NP_001269257.1	pescadillo homolog isoform 3
NM_014303.4	NP_055118.1	pescadillo homolog isoform 1

PES1 蛋白结构

Pescadillo_N

BRCT

0
100
200
300
400
500
588 a.a.

蛋白主名

其他名称

pescadillo homolog

pescadillo homolog 1, containing BRCT domain

PES1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PES1	O00541	BOP1	Homo sapiens	Q14137	Anti Tag CoIP	28514442
种属内	PES1	O00541	BOP1	Homo sapiens	Q14137	Anti Tag CoIP	35271311
种属内	PES1	O00541	BOP1	Homo sapiens	Q14137	Anti Tag CoIP	33961781
种属内	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Anti Tag CoIP	33961781
种属内	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Anti Tag CoIP	28514442
种属内	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Anti Tag CoIP	35271311
种属内	PES1	O00541	WDR12	Homo sapiens	Q9GZL7	Crosslink	30021884
种属内	PES1	O00541	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	PES1	O00541	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	PES1	O00541	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	PES1	O00541	FOXM1	Homo sapiens	Q08050	Pull Down	25609649
种属内	PES1	O00541	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
种属内	PES1	O00541	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
种属内	PES1	O00541	ATXN1	Homo sapiens	P54253	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0304A	Dapoxetine hydrochloride	Inhibitor	99.96%	否
HY-B0304	Dapoxetine	Inhibitor	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-157697	1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE		≥99.0%	否
HY-120991	1-Palmitoyl-2-linoleoyl-sn-glycero-3-PE		≥98.0%	否
HY-143671S	1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE-d11		≥99.0%	否
HY-115701	1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe	Inducer	/	否
HY-141617S	1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PE		/	否
HY-165116	1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE		/	否
HY-170459	18:1-12:0 Biotin PE		/	否
HY-P1695	Cinnamycin	Inhibitor	/	否
HY-P5809	Pe1b	Inhibitor	/	否
HY-RS10336	PES1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS11392	PTGS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-145473S	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11		/	否
HY-157415	1,2-Dierucoyl-sn-glycero-3-PE		/	否
HY-158750	1-1(Z)-Octadecenyl-2-adrenoyl-sn-glycero-3-pe		/	否
HY-158947	1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE		/	否
HY-158947S	1-1(Z)-Hexadecenyl-2-Palmitoyl-d9-sn-glycero-3-PE		/	否
HY-167894	DA-8031	Inhibitor	/	否
HY-W290532	(Rac)-Dapoxetine hydrochloride	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PES1	VGNC	VGNC:68788
Canis familiaris	PES1	VGNC	VGNC:44425
Macaca mulatta	PES1	VGNC	VGNC:75944
Bos taurus	PES1	VGNC	VGNC:32750
Mus musculus	PES1	MGD	MGI:1890613
Rattus norvegicus	PES1	RGD	RGD:1559814

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PES1 - pescadillo ribosomal biogenesis factor 1 Gene

关于 PES1

功能概要

PES1 基因产物(4)

PES1 蛋白结构

PES1 蛋白互作信息

关联疾病

直系同源

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PES1 - pescadillo ribosomal biogenesis factor 1 Gene

关于 PES1

功能概要

PES1 基因产物(4)

PES1 蛋白结构

PES1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z