2. Gene
  3. Ago1 - argonaute RISC catalytic subunit 1 Gene

Ago1 - argonaute RISC catalytic subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Eif2c1

基因 ID: 236511 | 基因类型: protein coding

关于 Ago1

功能概要

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to MicroRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

Ago1 基因产物(4)

mRNA Protein Name
NM_001317173.1 NP_001304102.1 protein argonaute-1 isoform 1x
NM_001317174.1 NP_001304103.1 protein argonaute-1 isoform 2
NM_001378879.1 NP_001365808.1 protein argonaute-1 isoform 3
NM_153403.3 NP_700452.2 protein argonaute-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
19536157 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22053081 MGI
enables miRNA binding IDA
IDA: 通过直接分析推断
22053081 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19269368 MGI
enables transcription cis-regulatory region binding IMP
IMP: 通过突变表型推断
22053081 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within miRNA metabolic process IDA
IDA: 通过直接分析推断
22053081 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
22053081 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
26764146 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
26764146 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22053081 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22053081 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
19898466 MGI
part of RISC complex IDA
IDA: 通过直接分析推断
19536157 MGI
located in cytosol IDA
IDA: 通过直接分析推断
22053081 MGI
located in nucleus IDA
IDA: 通过直接分析推断
22053081 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein argonaute-1

Piwi/Argonaute family protein meIF2C1

argonaute 1

argonaute RISC catalytic component 1

argonaute1

eIF-2C 1

eIF2C 1

eukaryotic translation initiation factor 2C, 1

mAgo1

Ago1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ago1 Q8CJG1 Trim32 Mus musculus Q8CH72
Anti Bait CoIP
19269368
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00452 AGO1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18906 Ago1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25397 Ago1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ago1 NCBI NCBI:26523
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