2. Gene
  3. PLXNB2 - plexin B2 Gene

PLXNB2 - plexin B2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丛素 B2

种属: Homo sapiens

同用名: MM1; PLEXB2; Nbla00445; dJ402G11.3

基因 ID: 23654 | 基因类型: protein coding

关于 PLXNB2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,274,979-50,307,646 (from NCBI)

This gene has 12 transcripts (splice variants), 318 orthologues and 8 paralogues. Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues.

功能概要

B 类丛蛋白的成员，例如 PLXNB2，是参与轴突导向和响应信号素的细胞迁移的跨膜受体 (Perrot 等人 (2002 年) [PubMed 12183458]) 。[OMIM 提供，2008 年 3 月]

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]

PLXNB2 基因产物(24)

mRNA Protein Name
NM_001376864.1 NP_001363793.1 plexin-B2 isoform 1 precursor
NM_001376865.1 NP_001363794.1 plexin-B2 isoform 2 precursor
NM_001376866.1 NP_001363795.1 plexin-B2 isoform 3 precursor
NM_001376867.1 NP_001363796.1 plexin-B2 isoform 3 precursor
NM_001376868.1 NP_001363797.1 plexin-B2 isoform 3 precursor
NM_001376869.1 NP_001363798.1 plexin-B2 isoform 3 precursor
NM_001376870.1 NP_001363799.1 plexin-B2 isoform 3 precursor
NM_001376871.1 NP_001363800.1 plexin-B2 isoform 3 precursor
NM_001376872.1 NP_001363801.1 plexin-B2 isoform 3 precursor
NM_001376873.1 NP_001363802.1 plexin-B2 isoform 3 precursor
NM_001376874.1 NP_001363803.1 plexin-B2 isoform 3 precursor
NM_001376875.1 NP_001363804.1 plexin-B2 isoform 3 precursor
NM_001376876.1 NP_001363805.1 plexin-B2 isoform 3 precursor
NM_001376877.1 NP_001363806.1 plexin-B2 isoform 3 precursor
NM_001376878.1 NP_001363807.1 plexin-B2 isoform 3 precursor
NM_001376879.1 NP_001363808.1 plexin-B2 isoform 3 precursor
NM_001376880.1 NP_001363809.1 plexin-B2 isoform 3 precursor
NM_001376881.1 NP_001363810.1 plexin-B2 isoform 3 precursor
NM_001376882.1 NP_001363811.1 plexin-B2 isoform 3 precursor
NM_001376883.1 NP_001363812.1 plexin-B2 isoform 4 precursor
NM_001376884.1 NP_001363813.1 plexin-B2 isoform 5 precursor
NM_001376885.1 NP_001363814.1 plexin-B2 isoform 5 precursor
NM_001376886.1 NP_001363815.1 plexin-B2 isoform 7 precursor
NM_012401.4 NP_036533.2 plexin-B2 isoform 3 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15184888 GOA
enables transmembrane signaling receptor activity IDA
IDA: 通过直接分析推断
29100074 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: 通过直接分析推断
16122393 GOA
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
16122393 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
29100074 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLXNB2 蛋白结构

Sema

Sema: Sema domain (35 - 438)

PSI

PSI: Plexin repeat (469 - 516)

TIG

TIG: IPT/TIG domain (803 - 892)

TIG

TIG: IPT/TIG domain (898 - 967)

TIG

TIG: IPT/TIG domain (983 - 1091)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1271 - 1805)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1838 a.a.
蛋白主名 其他名称

plexin-B2

PLXNB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLXNB2 O15031 MET Homo sapiens P08581
Anti Bait CoIP
15184888
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PLXNB2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78757 Plexin B2 Protein, Human (HEK293, His) O15031-1 (L20-R1160) ≥95%

PLXNB2 抗体

目录号 产品名 应用 反应物种
HY-P87044 Plexin B2 Antibody (YA6737) WB, ICC/IF, IHC-P Human

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, X-Linked 5

SCAX5

X-Linked Spinocerebellar Ataxia 5

X-Linked Non Progressive Cerebellar Ataxia
Walker-Warburg Syndrome

Hard Syndrome

Walker-Warburg Congenital Muscular Dystrophy

Cerebroocular Dysplasia-Muscular Dystrophy Syndrome

Cod-Md Syndrome

Chemke Syndrome

Hydrocephalus, Agyria And Retinal Dysplasia

Cerebroocular Dysgenesis

Cerebroocular Dysplasia Muscular Dystrophy Syndrome

Hard +/- E Syndrome

Pagon Syndrome

Warburg Syndrome

Hydrocephalus, Agyria, And Retinal Dysplasia

Mddga

Muscular Dystrophy-Dystroglycanopathy , Type A

Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A

Hydrocephalus-Agyria-Retinal Dysplasia Syndrome

Wws

Dystrophy, Muscular, Dystroglycanopathy, Type A
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10753 PLXNB2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLXNB2 RGD RGD:1305495
Mus musculus PLXNB2 MGD MGI:2154239
Felis catus PLXNB2 VGNC VGNC:68919
Canis familiaris PLXNB2 VGNC VGNC:44723
Bos taurus PLXNB2 VGNC VGNC:33062
Macaca mulatta PLXNB2 VGNC VGNC:76188
Others PLXNB2 NCBI
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