2. Gene
  3. FLRT1 - fibronectin leucine rich transmembrane protein 1 Gene

FLRT1 - fibronectin leucine rich transmembrane protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：纤连蛋白富亮氨酸跨膜蛋白 1

种属: Homo sapiens

同用名: SPG68

基因 ID: 23769 | 基因类型: protein coding

关于 FLRT1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,035,931-64,119,171 (from NCBI)

This gene has 2 transcripts (splice variants), 253 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 4.3), adrenal (RPKM 3.2) and 14 other tissues.

功能概要

该基因编码富含亮氨酸的纤连蛋白跨膜蛋白 (FLRT) 家族的成员。该家族成员可能在细胞粘附和/或受体信号传导中起作用。它们的蛋白质结构类似于细胞外基质中发现的富含亮氨酸的小蛋白聚糖。编码的蛋白质与另外两个家族成员 FLRT2 和 FLRT3 具有序列相似性。该基因在肾脏和大脑中表达。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

FLRT1 基因产物(2)

mRNA Protein Name
NM_001384466.1 NP_001371395.1 leucine-rich repeat transmembrane protein FLRT1
NM_013280.5 NP_037412.2 leucine-rich repeat transmembrane protein FLRT1

FLRT1 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (54 - 80)

LRR_8

LRR_8: Leucine rich repeat (128 - 189)

LRR_8

LRR_8: Leucine rich repeat (199 - 260)

LRR_8

LRR_8: Leucine rich repeat (271 - 328)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
蛋白主名 其他名称

leucine-rich repeat transmembrane protein FLRT1

fibronectin-like domain-containing leucine-rich transmembrane protein 1

重组 FLRT1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70925 FLRT1 Protein, Human (504a.a, HEK293, His) Q9NZU1 (I21-P524) ≥95%
HY-P76347 FLRT1 Protein, Human (524a.a, HEK293, His) Q9NZU1 (M1-P524) ≥95%

关联疾病

疾病名称 别名
Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome

SPOAN

Spastic Paraplegia, Optic Atropy, And Neuropathy

Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome

Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Spastic Paraplegia 8, Autosomal Dominant

SPG8

Hereditary Spastic Paraplegia 8

Autosomal Dominant Spastic Paraplegia Type 8

Autosomal Dominant Spastic Paraplegia 8

Paraplegia, Spastic, Autosomal Dominant, Type 8
Spastic Paraplegia 6, Autosomal Dominant

SPG6

Fsp3

Hereditary Spastic Paraplegia 6

Autosomal Dominant Spastic Paraplegia Type 6

Spastic Paraplegia 6

Familial Spastic Paraplegia Autosomal Dominant 3

Familial Spastic Paraplegia, Autosomal Dominant, 3

Autosomal Dominant Familial Spastic Paraplegia Type 3

Autosomal Dominant Spastic Paraplegia 6

Spastic Paraplegia-6

Paraplegia, Spastic, Type 6
Spastic Ataxia 3
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04984 FLRT1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FLRT1 VGNC VGNC:40904
Macaca mulatta FLRT1 VGNC VGNC:72675
Felis catus FLRT1 VGNC VGNC:62296
Mus musculus FLRT1 MGD MGI:3026647
Rattus norvegicus FLRT1 RGD RGD:1565152
Bos taurus FLRT1 VGNC VGNC:29038
Others FLRT1 NCBI
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