FLRT1 蛋白, Human (504a.a, HEK293, His)

FLRT1 is a key player in FGF-mediated signaling, activating MAP kinase and enhancing neurite outgrowth through FGFR1-mediated signaling. It helps increase the number and length of neurites. FLRT1 Protein, Human (504a.a, HEK293, His) is the recombinant human-derived FLRT1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLRT1 Protein, Human (504a.a, HEK293, His) is 504 a.a., with molecular weight of 60-85 kDa.

FLRT1 成为成纤维细胞生长因子 (FGF) 介导的信号通路的关键参与者，协调 MAP 激酶的激活。在神经突生长的背景下，FLRT1 通过促进 FGFR1 介导的下游 MAP 激酶的激活发挥着关键作用，导致神经突数量和长度显着增加。除了参与神经过程之外，FLRT1 还通过与 ADGRL1/LPHN1 和 ADGRL3 的相互作用参与细胞间粘附和细胞引导。这些相互作用，特别是与 FGFR1、ADGRL1/LPHN1 和 ADGRL3 的相互作用，强调了 FLRT1 的多功能性及其对从神经发育到细胞粘附和引导等多种细胞功能的贡献。

Immobilized Human FLRT1, His Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-FLRT1 Antibody, mFc Tag with the EC₅₀ of 3.5 ng/mL determined by ELISA.

Human

HEK293

C-His

Q9NZU1 (I21-P524)

23769  [NCBI]

IDSTTCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLAIHVKALTADSIRITWKATLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETSNAYVADETPVCAKAETADSYGPTTTLNQEQNAGPMASLP

60-85 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2 or PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.