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  3. Chrm3 - cholinergic receptor, muscarinic 3 Gene

Chrm3 - cholinergic receptor, muscarinic 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 24260 | 基因类型: protein coding

关于 Chrm3

功能概要

Enables several functions, including G protein-coupled acetylcholine receptor activity; G protein-coupled acetylcholine receptor binding activity; and acetylcholine binding activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; negative regulation of heart rate by acetylcholine; and positive regulation of vascular associated smooth muscle contraction. Located in several cellular components, including asymmetric synapse; axon terminus; and dendrite. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Apr 2022]

Chrm3 基因产物(1)

mRNA Protein Name
NM_012527.2 NP_036659.2 muscarinic acetylcholine receptor M3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled acetylcholine receptor activity IDA
IDA: 通过直接分析推断
1527051 RGD
enables G protein-coupled acetylcholine receptor binding IDA
IDA: 通过直接分析推断
9316844 RGD
enables acetylcholine binding IDA
IDA: 通过直接分析推断
1527051 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
20461055 RGD
enables quaternary ammonium group binding IDA
IDA: 通过直接分析推断
8075871 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: 通过直接分析推断
1527051 RGD
involved in G protein-coupled acetylcholine receptor signaling pathway IMP
IMP: 通过突变表型推断
15141107 RGD
involved in negative regulation of heart rate by acetylcholine IMP
IMP: 通过突变表型推断
9316844 RGD
involved in positive regulation of vascular associated smooth muscle contraction IMP
IMP: 通过突变表型推断
8428203 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
9316844 RGD
involved in response to acetylcholine IMP
IMP: 通过突变表型推断
8075871 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in asymmetric synapse IDA
IDA: 通过直接分析推断
8182478 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
8182478 RGD
located in dendrite IDA
IDA: 通过直接分析推断
8182478 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
8182478 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
1527051 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
8182478 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
8182478 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

muscarinic acetylcholine receptor M3

cholinergic receptor, muscarinic 3, cardiac

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02662 CHRM3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19180 Chrm3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25668 Chrm3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chrm3 NCBI NCBI:1131
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