1. Gene
  2. CHRM3 - cholinergic receptor muscarinic 3 Gene

CHRM3 - cholinergic receptor muscarinic 3 Gene

中文名称:胆碱能受体毒蕈碱 3

种属: Homo sapiens

同用名: HM3; PBS; EGBRS

基因 ID: 1131 | 基因类型: protein coding

关于 CHRM3

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:239,386,568-239,915,450 (from NCBI)

This gene has 12 transcripts (splice variants), 257 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.0), salivary gland (RPKM 2.4) and 12 other tissues.


毒蕈碱性胆碱能受体属于更大的 G 蛋白偶联受体家族。这些受体的功能多样性由乙酰胆碱的结合定义,包括腺苷酸环化酶抑制、磷酸肌醇变性和钾通道介导等细胞反应。毒蕈碱受体影响乙酰胆碱在中枢和周围神经系统中的许多作用。毒蕈碱性胆碱能受体 3 控制平滑肌收缩,其刺激导致腺体组织分泌。替代启动子的使用和替代剪接导致具有不同组织特异性的多个转录变体。[RefSeq 提供,2016 年 12 月]

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

CHRM3 基因产物(10)

mRNA Protein Name
NM_000740.4 NP_000731.1 muscarinic acetylcholine receptor M3
NM_001347716.2 NP_001334645.1 muscarinic acetylcholine receptor M3
NM_001375978.1 NP_001362907.1 muscarinic acetylcholine receptor M3
NM_001375979.1 NP_001362908.1 muscarinic acetylcholine receptor M3
NM_001375980.1 NP_001362909.1 muscarinic acetylcholine receptor M3
NM_001375981.1 NP_001362910.1 muscarinic acetylcholine receptor M3
NM_001375982.1 NP_001362911.1 muscarinic acetylcholine receptor M3
NM_001375983.1 NP_001362912.1 muscarinic acetylcholine receptor M3
NM_001375984.1 NP_001362913.1 muscarinic acetylcholine receptor M3
NM_001375985.1 NP_001362914.1 muscarinic acetylcholine receptor M3

CHRM3 蛋白结构


7tm_1: 7 transmembrane receptor (rhodopsin family) (85 - 544)

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  • 590 a.a.
蛋白主名 其他名称

muscarinic acetylcholine receptor M3

acetylcholine receptor, muscarinic 3


疾病名称 别名
Prune Belly Syndrome

Eagle-Barrett Syndrome

Abdominal Muscle Deficiency Syndrome


Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism


Eagle-Barret Syndrome

Urethral Obstruction Sequence

Obrinsky Syndrome

Triad Syndrome

Obrisnksy Syndrome


Early Urethral Obstruction Sequence

Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction

Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism

Abdomen Muscle Deficiency Syndrome

Abdomen Muscular Deficiency Syndrome

Abdominal Muscular Deficiency Syndrome

Abdominal Muscle Aplasia Syndrome

Low Compliance Bladder

Overactive Bladder

Hyperactivity Of Bladder

Hypertonic Bladder

Hypertonicity Of Bladder

Low Bladder Compliance

Oab - [Overactive Bladder]

Sjogren Syndrome

Sicca Syndrome

Sjogren'S Syndrome

Sjögren Syndrome

Sjogren-Gougerot Syndrome

Keratoconjunctivitis Sicca

Sjögren'S Syndrome


Dacryosialoadenopathia Atrophicans

Gougerot-Houwer-Sjogren Syndrome

Gougerot-Sjogren Syndrome

Keratoconjunctivitis Sicca-Xerostomia


Primary Sjogren Syndrome

Primary Sjogren-Gougerot Syndrome

Sjogrens Syndrome Primary

Sjogrens Syndrome

Dry Eye Syndromes

Cholinergic Urticaria
Aplasia Of Lacrimal And Salivary Glands


Congenital Absence Of Lacrimal Puncta And Salivary Glands


Absence Of Salivary Glands

Parotid Aplasia Or Hypoplasia

Congenital Absence Of Lacrimal Puncta Or Salivary Glands

Alsg - [Aplasia Of Lacrimal Or Salivary Glands]

Urofacial Syndrome 1

Urofacial Syndrome

Ochoa Syndrome

Hydronephrosis With Peculiar Facial Expression


Inverted Smile And Occult Neuropathic Bladder

Partial Facial Palsy With Urinary Abnormalities


Urofacial Ochoa'S Syndrome

Urofacial Syndrome Type 1

Facial Palsy, Partial, With Urinary Abnormalities

Hydronephrosis-Inverted Smile

Inverted Smile-Neurogenic Bladder

Hydronephrosis-Inverted Smile Syndrome

Inverted Smile-Neurogenic Bladder Syndrome

Partial Facial Palsy Partial With Urinary Abnormalities

Urologic Diseases

Physical Urticaria

Symptomatic Dermographism

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease


Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Chronic Obstructive Lung Disease

Chronic Obstructive Airway Disease

Pulmonary Disease, Chronic Obstructive, Susceptibility To


Severe Early-Onset Chronic Obstructive Pulmonary Disease

Pulmonary Disease Chronic Obstructive

Pulmonary Disease, Obstructive, Chronic, Susceptibility To

Chronic Obstructive Pulmonary Disease Of Horses

Common Cold

Upper Respiratory Infections

Copd - [Chronic Obstructive Pulmonary Disease]

Coad - [Chronic Obstructive Airways Disease]

Cold - [Chronic Obstructive Lung Disease]

Chronic Airway Disease Nos

Chronic Airways Limitation, Unspecified

Chronic Obstructed Airway, Unspecified

Chronic Obstructive Airway Disease, Unspecified

Chronic Obstructive Airway, Unspecified

Obstructive Lung Disease Nos

Chronic Obstructive Lung Disease Nos

Chronic Obstructive Lung Nos

Obstructive Pulmonary Disease Nos

Exacerbation Copd Nos

Acute Exacerbation Copd

Functional Colonic Disease

Colonic Diseases, Functional

Colonic Pseudo-Obstruction

Primary Chronic Pseudo-Obstruction Of Colon


Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Bos taurus CHRM3 VGNC VGNC:27320
Canis familiaris CHRM3 VGNC VGNC:39233
Mus musculus CHRM3 MGD MGI:88398
Felis catus CHRM3 VGNC VGNC:60875
Rattus norvegicus CHRM3 RGD RGD:2343
Macaca mulatta CHRM3 VGNC VGNC:71043