Gja1 - gap junction protein, alpha 1 Gene

种属: Rattus norvegicus

同用名: Cx43; Cxnk1

基因 ID: 24392 | 基因类型: protein coding

关于 Gja1

功能概要

Enables connexin binding activity; gap junction channel activity; and protein domain specific binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of cell population proliferation; and reproductive structure development. Located in several cellular components, including endosome; fascia adherens; and gap junction. Part of connexin complex. Used to study Parkinsonism; amnestic disorder; high grade glioma; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; borna disease; ischemia (multiple); and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive craniometaphyseal dysplasia; congenital heart disease (multiple); erythrokeratodermia variabilis (multiple); oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (Gap Junction Protein alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Gja1 基因产物(1)

mRNA	Protein	Name
NM_012567.2	NP_036699.1	gap junction alpha-1 protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables PDZ domain binding	IPI IPI: 通过物理相互作用推断	14699011	RGD
enables SH3 domain binding	EXP EXP: 通过实验结果推断	15492000	RGD
enables SH3 domain binding	IDA IDA: 通过直接分析推断	14699011	RGD
enables SH3 domain binding	IPI IPI: 通过物理相互作用推断	14699011	RGD
enables connexin binding	IPI IPI: 通过物理相互作用推断	11557558	RGD
enables disordered domain specific binding	IPI IPI: 通过物理相互作用推断	19808665	RGD
enables gap junction channel activity	IDA IDA: 通过直接分析推断	15048573	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	15181016	RGD
enables protein domain specific binding	IDA IDA: 通过直接分析推断	17008717	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ATP transport	IMP IMP: 通过突变表型推断	16731531	RGD
involved in cell-cell signaling	IDA IDA: 通过直接分析推断	15048573	RGD
involved in cellular response to mechanical stimulus	IEP IEP: 通过表达模式推断	10631100	RGD
involved in cellular response to parathyroid hormone stimulus	IEP IEP: 通过表达模式推断	11159864	RGD
involved in chronic inflammatory response	IMP IMP: 通过突变表型推断	23165424	RGD
involved in decidualization	IEP IEP: 通过表达模式推断	8924512	RGD
involved in endothelium development	IEP IEP: 通过表达模式推断	10990491	RGD
involved in epididymis development	IEP IEP: 通过表达模式推断	12388089	RGD
involved in heart development	IEP IEP: 通过表达模式推断	8944820	RGD
involved in maintenance of protein localization in endoplasmic reticulum	IDA IDA: 通过直接分析推断	15817491	RGD
involved in negative regulation of DNA biosynthetic process	IDA IDA: 通过直接分析推断	14702389	RGD
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: 通过突变表型推断	19377854	RGD
involved in negative regulation of cell growth	IMP IMP: 通过突变表型推断	15181016	RGD
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	12952975	RGD
involved in negative regulation of endothelial cell proliferation	IMP IMP: 通过突变表型推断	18172080	RGD
involved in neuron projection morphogenesis	IMP IMP: 通过突变表型推断	16731531	RGD
involved in positive regulation of behavioral fear response	IMP IMP: 通过突变表型推断	22665389	RGD
involved in positive regulation of cell communication by chemical coupling	IMP IMP: 通过突变表型推断	15678088	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: 通过突变表型推断	22577485	RGD
involved in positive regulation of establishment of Sertoli cell barrier	IMP IMP: 通过突变表型推断	26678449	RGD
involved in positive regulation of glomerular filtration	IMP IMP: 通过突变表型推断	18046320	RGD
involved in positive regulation of insulin secretion	IMP IMP: 通过突变表型推断	24301293	RGD
involved in positive regulation of meiotic nuclear division	IMP IMP: 通过突变表型推断	26678449	RGD
involved in positive regulation of protein catabolic process	IDA IDA: 通过直接分析推断	12952975	RGD
involved in positive regulation of vasoconstriction	IMP IMP: 通过突变表型推断	21414209	RGD
involved in regulation of actin filament organization	IMP IMP: 通过突变表型推断	26678449	RGD
involved in regulation of apoptotic process	IMP IMP: 通过突变表型推断	17761141	RGD
involved in regulation of bicellular tight junction assembly	IMP IMP: 通过突变表型推断	19509333	RGD
involved in regulation of calcium ion transport	IMP IMP: 通过突变表型推断	16878174	RGD
involved in regulation of cell communication by electrical coupling	IDA IDA: 通过直接分析推断	11557558	RGD
involved in regulation of transmembrane transporter activity	IMP IMP: 通过突变表型推断	15284189	RGD
involved in response to estradiol	IEP IEP: 通过表达模式推断	25798059	RGD
involved in response to fluid shear stress	IEP IEP: 通过表达模式推断	15558296	RGD
involved in response to glucose	IEP IEP: 通过表达模式推断	21567444	RGD
involved in response to ischemia	IEP IEP: 通过表达模式推断	24728265	RGD
involved in response to lipopolysaccharide	IEP IEP: 通过表达模式推断	10909894	RGD
involved in response to pH	IDA IDA: 通过直接分析推断	14699011	RGD
involved in response to peptide hormone	IEP IEP: 通过表达模式推断	12700188	RGD
involved in response to retinoic acid	IEP IEP: 通过表达模式推断	9570757	RGD
involved in spermatogenesis	IMP IMP: 通过突变表型推断	26678449	RGD
involved in transmembrane transport	IDA IDA: 通过直接分析推断	15284189	RGD
involved in vascular transport	IMP IMP: 通过突变表型推断	16878174	RGD
involved in vasodilation	IMP IMP: 通过突变表型推断	15301736	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	18162583	RGD
part of connexin complex	IDA IDA: 通过直接分析推断	1371548	RGD
part of connexin complex	IMP IMP: 通过突变表型推断	19808665	RGD
located in early endosome	IDA IDA: 通过直接分析推断	16162097	RGD
located in endosome	IDA IDA: 通过直接分析推断	19808888	RGD
located in fascia adherens	IDA IDA: 通过直接分析推断	9851942	RGD
located in gap junction	IDA IDA: 通过直接分析推断	15048573	RGD
located in intercalated disc	IDA IDA: 通过直接分析推断	25332002	RGD
located in late endosome	IDA IDA: 通过直接分析推断	16162097	RGD
located in membrane	IDA IDA: 通过直接分析推断	19723622	RGD
located in membrane raft	IDA IDA: 通过直接分析推断	18162583	RGD
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	17107662	RGD
located in multivesicular body	IDA IDA: 通过直接分析推断	16162097	RGD
located in plasma membrane	IDA IDA: 通过直接分析推断	18162583	RGD
located in plasma membrane	IMP IMP: 通过突变表型推断	17673670	RGD
part of protein-containing complex	IMP IMP: 通过突变表型推断	15492000	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

gap junction alpha-1 protein

connexin 43	connexin k1
gap junction 43 kDa heart protein	gap junction membrane channel protein alpha 1

Gja1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Gja1	P08050	Sgsm3	Mus musculus	Q8VCZ6	Y2H	15709751
种属间	Gja1	P08050	Sgsm3	Mus musculus	Q8VCZ6	Anti Tag CoIP	15709751
种属间	Gja1	P08050	Sgsm3	Mus musculus	Q8VCZ6	Affinity Chrom	15709751
种属间	Gja1	P08050	UBQLN4	Homo sapiens	Q9NRR5	Anti Bait CoIP	20940304

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05440	GJA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18762	Gja1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25249	Gja1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Gja1	NCBI	NCBI:2697

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4