2. Gene
  3. Igfbp3 - insulin-like growth factor binding protein 3 Gene

Igfbp3 - insulin-like growth factor binding protein 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: IGF-BP3

基因 ID: 24484 | 基因类型: protein coding

关于 Igfbp3

功能概要

Enables insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to estradiol stimulus; and response to peptide hormone. Located in extracellular space; heterochromatin; and platelet alpha granule. Part of insulin-like growth factor binary complex and insulin-like growth factor ternary complex. Used to study impotence. Biomarker of congenital diaphragmatic hernia; impotence; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (Insulin like growth factor binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Igfbp3 基因产物(1)

mRNA Protein Name
NM_012588.2 NP_036720.2 insulin-like growth factor-binding protein 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables insulin-like growth factor II binding IPI
IPI: 通过物理相互作用推断
9346943 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9346943 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to Thyroglobulin triiodothyronine IEP
IEP: 通过表达模式推断
8674839 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
8674839 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
9449625 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
22067319 RGD
involved in negative regulation of testosterone secretion IMP
IMP: 通过突变表型推断
25582342 RGD
involved in positive regulation of apoptotic DNA fragmentation IMP
IMP: 通过突变表型推断
15125883 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15935983 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
15055478 RGD
involved in response to caloric restriction IEP
IEP: 通过表达模式推断
17635417 RGD
involved in response to growth hormone IEP
IEP: 通过表达模式推断
19916171 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
22805023 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
8776722 RGD
involved in response to insulin-like growth factor stimulus IEP
IEP: 通过表达模式推断
8776722 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
15930173 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
7536658 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
20042659 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
15990634 RGD
located in heterochromatin IDA
IDA: 通过直接分析推断
15125883 RGD
part of insulin-like growth factor binary complex IDA
IDA: 通过直接分析推断
9346943 RGD
part of insulin-like growth factor ternary complex IDA
IDA: 通过直接分析推断
9346943 RGD
located in platelet alpha granule IDA
IDA: 通过直接分析推断
9449625 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

insulin-like growth factor-binding protein 3

IBP-3

IGF-binding protein 3

IGFBP-3

insulin-like growth factor-binding protein (IGF-BP3)

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W074890 Palmitoylglycine Modulator 99.84% 否
HY-110135A NBI-31772 hydrate Inhibitor 99.42% 否
HY-N3316 Martynoside Antagonist 99.41% 否
HY-RS06626 IGFBP3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-P10403 IGFBP-3 peptide / 否
HY-RS17430 Igfbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23885 Igfbp3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Igfbp3 NCBI NCBI:3486
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