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  3. NBI-31772 hydrate

NBI-31772 hydrate 

目录号: HY-110135A 纯度: >98.0%
产品使用指南

NBI-31772 hydrate 是胰岛素样生长因子 IGFIGFBP 相互作用的有效抑制剂。NBI-31772 hydrate 也是一种非肽类配体,可从其结合蛋白复合物 IGF-I/IGFBP-3 中释放生物活性 IGF-I (对六种人类亚型的 Ki=1-24 nM) 。具有抗焦虑和抗抑郁作用。

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NBI-31772 hydrate Chemical Structure

NBI-31772 hydrate Chemical Structure

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Size Price Stock Quantity
5 mg ¥4700 In-stock
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Description

NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects[1][2][3].

In Vivo

NBI-31772 (5-100 μg; icv; immediately or at 1, 2, or, 3 hours after MCAO) at the time of ischemia onset also dose-dependently reduced infarct size, and the highest dose (100 μg) significantly reduced both total and cortical infarct volume[3].

Animal Model: Sprague-Dawley rats (subtemporal middle cerebral artery occlusion model, MCAO)[3]
Dosage: 5-100 μg
Administration: Icv; immediately or at 1, 2, or, 3 hours after MCAO
Result: Resulted in a significant reduction of the total and cortical lesion volume.
Molecular Weight

372.82

Formula

C₁₇H₁₁NO₇.₇/₄H₂O

SMILES

O=C(C1=CC(O)=C(O)C=C1)C2=NC(C(O)=O)=CC3=C2C=C(O)C(O)=C3.[7/4].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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× = ×
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Keywords:

NBI-31772NBI31772NBI 31772IGF-1RInsulin-like growth factor-1 receptorinteractionIGFIGFBPnonpeptidecomplexanxiolyticantidepressantInhibitorinhibitorinhibit

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产品名称:
NBI-31772 hydrate
目录号:
HY-110135A
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