2. Gene
  3. Atr - ataxia telangiectasia and Rad3 related Gene

Atr - ataxia telangiectasia and Rad3 related Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：共济失调毛细血管扩张与Rad3 相关

种属: Mus musculus

基因 ID: 245000 | 基因类型: protein coding

关于 Atr

Chromosome 9: 95,739,650-95,833,834 forward strand.GRCm39:CM001002.3

This gene has 13 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 67 phenotypes. Broad expression in testis adult (RPKM 8.1), CNS E11.5 (RPKM 3.4) and 21 other tissues.

功能概要

该基因编码的蛋白可启动蛋白激酶活性。通过端粒酶和复制叉处理参与端粒维护的正向调节。作用于多个过程的上游或内部，包括 DNA 损伤检查点信号；胚胎植入；和蛋白质磷酸化。位于 XY 体内。以多种结构表达，包括消化系统；中枢神经系统;早孕;眼睛;和性腺。用于研究塞克尔综合征。该基因的人类直系同源物与 Seckel 综合征 1 相关；腺样囊性癌；结肠癌;肺癌；和胰腺癌。与人类 ATR（ATR 丝氨酸/苏氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity. Involved in positive regulation of telomere maintenance via Telomerase and replication fork processing. Acts upstream of or within several processes, including DNA damage checkpoint signaling; embryo implantation; and protein phosphorylation. Located in XY body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and gonad. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic Cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atr 基因产物(1)

mRNA Protein Name
NM_019864.1 NP_063917.1 serine/threonine-protein kinase ATR
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15680327 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
15364958 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
12937170 MGI
acts upstream of or within DNA damage response IDA
IDA: 通过直接分析推断
15983387 MGI
acts upstream of or within DNA repair IDA
IDA: 通过直接分析推断
15364958 MGI
acts upstream of or within chromosome organization IMP
IMP: 通过突变表型推断
10691732 MGI
acts upstream of or within embryo implantation IMP
IMP: 通过突变表型推断
10691732 MGI
involved in positive regulation of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
26586427 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
15364958 MGI
acts upstream of or within regulation of protein binding IDA
IDA: 通过直接分析推断
15983387 MGI
involved in replication fork processing IMP
IMP: 通过突变表型推断
29125140 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ATR-ATRIP complex IPI
IPI: 通过物理相互作用推断
11721054 MGI
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
29279380 MGI
located in XY body IDA
IDA: 通过直接分析推断
18316482 MGI
located in chromosome IDA
IDA: 通过直接分析推断
22549958 MGI
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: 通过直接分析推断
29279380 MGI
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
31839538 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
29279380 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Atr 蛋白结构

UME

UME: smart00802 (1118 - 1224)

NR_LBD

NR_LBD: cl11397 (1528 - 1606)

FAT

FAT: pfam02259 (1770 - 2091)

TEL1

TEL1: cl34875 (2122 - 2640)

PIKKc_ATR

PIKKc_ATR: cd00892 (2289 - 2563)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2641 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase ATR

ataxia telangiectasia and Rad3-related protein

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-19323 Ceralasertib Inhibitor 99.76% Phase 3
HY-13902 Berzosertib Inhibitor 99.67% Phase 2
HY-101566 Elimusertib Inhibitor 99.91% Phase 2
HY-139609 Camonsertib Inhibitor 99.75% Phase 2
HY-101566A Elimusertib hydrochloride Inhibitor 99.85% Phase 2
Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14731 VE-821 Inhibitor 99.67% 否
HY-136270 Gartisertib Inhibitor 99.77% 否
HY-15557 AZ20 Inhibitor 99.40% 否
HY-15520 CGK733 Inhibitor 99.83% 否
HY-15521 ETP-46464 Inhibitor 99.54% 否
HY-N6954 Garcinone C Activator 99.66% 否
HY-159480 AD1058 Inhibitor 98.11% 否
HY-13816 NU6027 Inhibitor 99.04% 否
HY-P10280 ATR kinase substrate peptide Inhibitor 99.17% 否
HY-147190 ATR-IN-19 Inhibitor / 否
HY-147569 ATR-IN-17 Inhibitor / 否
HY-157767 Abd110 Inhibitor / 否
HY-147570 ATR-IN-18 Inhibitor / 否
HY-161838 ICT10336 Inhibitor / 否
HY-174828 ATR/PARP1-IN-1 Inhibitor / 否
HY-153729 ATR-IN-29 Inhibitor / 否
HY-153393 ATR-IN-21 Inhibitor / 否
HY-147568 ATR-IN-16 Inhibitor / 否
HY-144214 ATR-IN-10 Inhibitor / 否
HY-141478 Antitumor agent-28 Inhibitor / 否
HY-147566 ATR-IN-14 Inhibitor / 否
HY-147565 ATR-IN-13 Inhibitor / 否
HY-147567 ATR-IN-15 Inhibitor / 否
HY-151915 ATR-IN-20 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atr NCBI NCBI:545
Macaca fascicularis Atr NCBI NCBI:101926636
Rattus norvegicus Atr NCBI NCBI:685055
Macaca mulatta Atr NCBI NCBI:714443
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