1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Telomerase

Telomerase (端粒酶)

Telomerase is a ribonucleoprotein that is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and hinders the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied, only 100–200 nucleotides are lost, which causes no damage to the organism's DNA. Telomerase is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells.

Telomerase 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-17353
    BIBR 1532 Inhibitor 99.94%
    BIBR 1532 是一种有效的,选择性的 telomerase 非竞争性抑制剂,IC50 值为 100 nM。
  • HY-108477
    TMPyP4 tosylate Inhibitor ≥98.0%
    TMPyP4 tosylate (TMP 1363) 是一种四链体 (G-quadruplex) 特异性配体,可抑制 G-四链体和 IGF-1 之间的相互作用。TMPyP4 tosylate (TMP 1363) 是一种端粒酶 (telomerase) 抑制剂,在骨肉瘤细胞系中具有抗肿瘤作用。
  • HY-N0424
    Cycloastragenol Inhibitor ≥98.0%
    Cycloastragenol 是一种天然的四环三萜类化合物,在筛选黄芪提取物时鉴定出具有抗衰老活性。Cycloastragenol 是一种有效的端粒酶 (telomerase) 激活剂。Cycloastragenol 还具有其他药理作用,包括抗炎和抗氧化特性。
  • HY-15595A
    360A iodide Inhibitor ≥98.0%
    360A iodide 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
  • HY-P1149A
    Epitalon TFA Activator 99.23%
    Epitalon TFA 是一种抗衰老剂和端粒酶激活剂。Epitalon TFA 对小鼠自发性肿瘤的发展具有抑制作用,具有 geroprotective 作用,通过鼻内给药可增加神经元活性。Epitalon TFA 可用于癌症,衰老和色素性视网膜炎。
  • HY-113679
    Ceramides Mixture Inhibitor ≥98.0%
    Ceramides Mixture 是一种内源性神经酰胺,由含羟基和非羟基脂肪酸的神经酰胺组成。Ceramides Mixture 是表皮渗透屏障的主要脂质成分。Ceramides Mixture 参与生长抑制,细胞周期停滞和端粒酶 (telomerase) 活性的调节。
  • HY-126482
    Telomerase-IN-2 Inhibitor 98.71%
    Telomerase-IN-2 是一种端粒酶 (telomerase) 抑制剂,通过降低角化不良蛋白的表达来抑制其活性,IC50 值为 0.89 µM。Telomerase-IN-2 具有抗癌作用。
  • HY-15595
    360A Inhibitor
    360A 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
  • HY-15225
    Telomestatin Inhibitor
    Telomestatin 是一种非常有效的端粒酶 (telomerase) 抑制剂,可从 Streptomyces anulatus 3533-SV4 中分离得到。Telomestatin 选择性地促进分子内 G-quadruplexes 的形成,特别是人类端粒序列 d[T2AG3]4 的形成。Telomestatin 是一种 ADC 细胞毒素,可用于癌症研究。
  • HY-126483
    Telomerase-IN-3 Inhibitor
    Telomerase-IN-3 是一种端粒酶 (telomerase) 抑制剂,直接靶向 hTERT 启动子活性。hTERT 是维持端粒酶活性的关键成分。
  • HY-U00268
    Telomerase-IN-1 Inhibitor
    Telomerase-IN-1 是一个端粒酶抑制剂,IC50 值为 0.19 μM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.