1. Gene
  2. Mbp - myelin basic protein Gene

Mbp - myelin basic protein Gene

种属: Rattus norvegicus

同用名: Mbps

基因 ID: 24547 | 基因类型: protein coding

关于 Mbp

功能概要

The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]

Mbp 基因产物(6)

mRNA Protein Name
NM_001025289.1 NP_001020460.1 Golli-Mbp isoform 1
NM_001025291.1 NP_001020462.1 myelin basic protein isoform 1
NM_001025292.1 NP_001020463.1 myelin basic protein isoform 2
NM_001025293.1 NP_001020464.1 myelin basic protein isoform 3
NM_001025294.1 NP_001020465.1 myelin basic protein isoform 4
NM_017026.2 NP_058722.1 myelin basic protein isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17610306 RGD
enables structural constituent of myelin sheath IMP
IMP: 通过突变表型推断
10212300 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in myelination IMP
IMP: 通过突变表型推断
15869936 RGD
involved in negative regulation of axonogenesis IMP
IMP: 通过突变表型推断
12210134 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
21892882 RGD
involved in response to mercury ion IEP
IEP: 通过表达模式推断
22835759 RGD
involved in response to progesterone IDA
IDA: 通过直接分析推断
12887683 RGD
involved in response to tumor necrosis factor IEP
IEP: 通过表达模式推断
23735240 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
21401967 RGD
located in compact myelin IDA
IDA: 通过直接分析推断
2462020 RGD
located in myelin sheath IDA
IDA: 通过直接分析推断
17960831 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

myelin basic protein

Golli-Mbp

MBP S

myelin basic protein Golli-mbp

myelin basic protein S

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mbp NCBI NCBI:4155
Canis lupus familiaris Mbp NCBI
Mus musculus Mbp NCBI NCBI:17196
Macaca mulatta Mbp NCBI NCBI:710350