2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. NCGC00249987

NCGC00249987 是一种高度选择性和变构 Eya2 的 Tyr 磷酸酶活性的抑制剂，对 Eya2 ED 和 MBP-Eya2 FL 的 IC50 分别为 3 μM 和 6.9 μM。NCGC00249987 专门针对肺癌细胞的迁移，侵袭伪足形成和侵袭。

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NCGC00249987 Chemical Structure

NCGC00249987 Chemical Structure

CAS No. : 1384864-80-5

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规格 价格 是否有货 数量
1 mg ￥500
In-stock
5 mg ￥1150
In-stock
10 mg ￥2050
In-stock
25 mg ￥3700
In-stock
50 mg ￥5600
In-stock
100 mg ￥8400
In-stock
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500 mg   询价  

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NCGC00249987 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells[1].

IC50 & Target

IC50: 3 μM (Eya2 ED) and 6.9 μM (MBP-Eya2 FL)[1]
体外研究
(In Vitro)

NCGC00249987 inhibits Eya2 ED (C-terminal Eya Domain). NCGC00249987 inhibits full length Eya2 including but not other Eya family members[1].
NCGC00249987 binding leads to a conformational change of the active site that is unfavorable for Mg2+ binding, thereby inhibiting Eya2’s Tyr phosphatase activity[1].
NCGC00249987 (5, 10 μM) treatment effectively suppresses migration, invadopodia formation and invasion in Eya2 WT expressing Calu-6 cells, but not in EV Calu-6 cells. NCGC00249987 does not inhibit cell growth or survival[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCGC00249987 相关抗体:
分子量

342.35

Formula

C16H11FN4O2S
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

NCGC00249987 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCGC002499871384864-80-5NCGC 00249987NCGC-00249987PhosphataseTyrphosphataseEya2EDMBP-Eya2FLmigrationinvadopodiaformationinvasionlungcancerC-terminalEyaDomain,Inhibitorinhibitorinhibit

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产品名称：
NCGC00249987
目录号：
HY-133512
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