2. Gene
  3. Rb1 - RB transcriptional corepressor 1 Gene

Rb1 - RB transcriptional corepressor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 24708 | 基因类型: protein coding

关于 Rb1

功能概要

Predicted to enable several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of protein kinase activity; and spermatogenesis. Located in nucleus. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in nervous system Cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder Cancer. Orthologous to human RB1 (RB transcriptional corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rb1 基因产物(1)

mRNA Protein Name
NM_017045.2 NP_058741.2 retinoblastoma-associated protein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
8945638 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic signaling pathway IMP
IMP: 通过突变表型推断
24027266 RGD
involved in negative regulation of cell cycle IMP
IMP: 通过突变表型推断
24027266 RGD
involved in negative regulation of hepatocyte apoptotic process IMP
IMP: 通过突变表型推断
8649852 RGD
involved in negative regulation of protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
24027266 RGD
involved in negative regulation of tau-protein kinase activity IMP
IMP: 通过突变表型推断
24027266 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
15659706 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

retinoblastoma-associated protein

Retinoblastoma 1 (including osteosarcoma)

pRb

pp105

Rb1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Rb1 P33568 Rbbp9 Rattus norvegicus O88350
Anti Bait CoIP
9697699
种属内
Rb1 P33568 E2f1 Rattus norvegicus O09139
Anti Bait CoIP
9697699
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0039 Ginsenoside Rb1 99.75% 否
HY-N0904 Ginsenoside C-K Inhibitor 99.92% 否
HY-125848 Ginsenoside F2 Inducer 99.95% 否
HY-124962 D-NMAPPD 99.74% 否
HY-N0039R Ginsenoside Rb1 (Standard) 99.26% 否
HY-N7678 Gypenoside LXXV 98.80% 否
HY-RS11713 RB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-N0904R Ginsenoside C-K (Standard) Inhibitor / 否
HY-RS06683 IL12RB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11714 RB1CC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11754 RBM45 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174616 Human IL23R mRNA / 否
HY-174640 Human IL12RB1 mRNA / 否
HY-176853 Myt1-IN-6 Inhibitor / 否
HY-N8030 Pseudoginsenoside Rg3 / 否
HY-RS16852 Rb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23293 Rb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990776 Vimekofusp / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rb1 NCBI NCBI:5925
Canis familiaris Rb1 NCBI NCBI:476915
Macaca fascicularis Rb1 NCBI NCBI:102145859
Mus musculus Rb1 NCBI NCBI:19645
Macaca mulatta Rb1 NCBI NCBI:704871
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