2. Gene
  3. Tap1 - transporter 1, ATP binding cassette subfamily B member Gene

Tap1 - transporter 1, ATP binding cassette subfamily B member Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cim; Tap2; Abcb2

基因 ID: 24811 | 基因类型: protein coding

关于 Tap1

功能概要

Enables several functions, including ATP hydrolysis activity; TAP binding activity; and adenyl ribonucleotide binding activity. Contributes to peptide antigen binding activity. Involved in peptide transport and protection from natural killer cell mediated cytotoxicity. Located in intracellular membrane-bounded organelle. Part of TAP complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune disease (multiple); bronchial disease (multiple); diffuse scleroderma; and lung disease (multiple). Orthologous to human TAP1 (transporter 1, ATP binding cassette subfamily B member). [provided by Alliance of Genome Resources, Apr 2022]

Tap1 基因产物(1)

mRNA Protein Name
NM_032055.4 NP_114444.2 antigen peptide transporter 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP binding IDA
IDA: 通过直接分析推断
15611256 RGD
enables ATP binding IDA
IDA: 通过直接分析推断
12047747 RGD
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
17018292 RGD
enables MHC class I protein binding IDA
IDA: 通过直接分析推断
12047747 RGD
enables TAP1 binding IPI
IPI: 通过物理相互作用推断
12047747 RGD
enables TAP2 binding IPI
IPI: 通过物理相互作用推断
12047747 RGD
enables nucleotide binding IDA
IDA: 通过直接分析推断
14622282 RGD
contributes to peptide antigen binding IDA
IDA: 通过直接分析推断
10508608 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18802093 RGD
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
12047747 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
11595746 RGD
enables tapasin binding IDA
IDA: 通过直接分析推断
12047747 RGD
enables tapasin binding IPI
IPI: 通过物理相互作用推断
12047747 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptide transport IMP
IMP: 通过突变表型推断
15611256 RGD
involved in protection from natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
8120379 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MHC class I peptide loading complex IDA
IDA: 通过直接分析推断
17947644 RGD
part of TAP complex IDA
IDA: 通过直接分析推断
11595746 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

antigen peptide transporter 1

APT1

ATP-binding cassette sub-family B member 2

peptide transporter TAP1

transporter 1 ABC (ATP binding cassette)

transporter 1 ATP-binding cassette sub-family B

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P5865 Tap1a Inhibitor / 否
HY-RS12607 SEC14L2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14201 TAP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17593 Tap1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24053 Tap1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tap1 NCBI NCBI:6890
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