2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Tap1a

Tap1a  (Synonyms: Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a)

目录号: HY-P5865
产品使用指南 技术支持

Tap1a (Theraphotoxin-Tap1a) 是一种抑制钠通道 (sodium channels) 的蜘蛛毒液肽，对 Nav1.7 和 Nav1.1 的 IC50 分别为 80 nM 和 301 nM。Tap1a 具有缓解疼痛作用。

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Custom Peptide Synthesis

Tap1a

Tap1a Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

Tap1a 相关抗体

Top Publications Citing Use of Products

查看 Sodium Channel 亚型特异性产品:

查看所有亚型
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects[1].

IC50 & Target

IC50: 80 nM (Nav1.7), 301 nM (Nav1.1)[1]
分子量

4182.68

Formula

C174H258N52O55S7
Sequence

Asp-Asp-Cys-Leu-Gly-Met-Phe-Ser-Ser-Cys-Asp-Pro-Asn-Asn-Asp-Lys-Cys-Cys-Pro-Asn-Arg-Lys-Cys-Ser-Arg-Lys-Asp-Gln-Trp-Cys-Lys-Tyr-Gln-Leu-Trp (Disulfide bridge:Cys3-Cys18, Cys10-Cys23, Cys17-Cys30)
Sequence Shortening

DDCLGMFSSCDPNNDKCCPNRKCSRKDQWCKYQLW (Disulfide bridge:Cys3-Cys18, Cys10-Cys23, Cys17-Cys30)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tap1a 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tap1aTheraphotoxin-Tap1a TRTX-Tap1a µ/ω-TRTX-Tap1aSodium ChannelNa channelsNa+ channelsTheraphosa apophysisanalgesic effectpainful diabetic neuropathyspared nerve injury-induced neuropathychronic visceral painInhibitorinhibitorinhibit

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