FRZB - frizzled related protein Gene

中文名称：卷曲相关蛋白

种属: Homo sapiens

同用名: FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN

基因 ID: 2487 | 基因类型: protein coding

关于 FRZB

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,833,275-182,866,637 (from NCBI)

This gene has 1 transcript (splice variant), 294 orthologues, 15 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 48.5), gall bladder (RPKM 25.9) and 20 other tissues.

功能概要

该基因编码的蛋白质是一种分泌蛋白，参与骨骼发育的调节。该基因的缺陷是女性特异性骨关节炎 (OA) 易感性的原因。[RefSeq 提供，2010 年 4 月]

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

FRZB 基因产物(1)

mRNA	Protein	Name
NM_001463.4	NP_001454.2	secreted frizzled-related protein 3 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of Wnt signaling pathway	IDA IDA: 通过直接分析推断	20208569	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	17471511	GOA
involved in negative regulation of cell growth	IDA IDA: 通过直接分析推断	20208569	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	20208569	GOA
acts upstream of or within positive regulation of apoptotic process	IGI IGI: 通过遗传相互作用推断	18166153	GOA
acts upstream of or within positive regulation of fat cell differentiation	IDA IDA: 通过直接分析推断	12055200	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FRZB 蛋白结构

NTR

0
100
200
300
325 a.a.

蛋白主名

其他名称

secreted frizzled-related protein 3

frezzled

FRZB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FRZB	Q92765	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
种属内	FRZB	Q92765	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FRZB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75780	FRZB Protein, Human (HEK293, His)	Q92765/NP_001454.2 (A32-N325)	≥95%

关联疾病

疾病名称

别名

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Holzgreve Syndrome

Holzgreve-Wagner-Rehder Syndrome	Holzgreve Wagner Rehder Syndrome
Complex Congenital Heart Defect, Renal Agenesis And Cleft Lip And Palate	Cleft Palate-Potter Sequence-Congenital Heart Anomalies-Mesoaxial Polydactyly-Multiple Malformations Syndrome

Monofixation Syndrome

Retinal Degeneration

Degeneration Of Retina

Localized Osteosarcoma

Localised Osteogenic Sarcoma	Localised Osteosarcoma
Localized Osteogenic Sarcoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Sclerosteosis

Cortical Hyperostosis With Syndactyly	Sost
Cortical Hyperostosis-Syndactyly Syndrome

Van Buchem Disease

Hyperostosis Corticalis Generalisata	Hyperphosphatasemia Tarda
VBCH	Sost-Related Sclerosing Bone Dysplasia
Endosteal Hyperostosis Autosomal Recessive	Sclerosteosis
Endosteal Hyperostosis, Autosomal Recessive	Hyperotosis Corticalis Generalisata Familiaris
Sost Sclerosing Bone Dysplasia	Smith-Lemli-Opitz Syndrome

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Nanophthalmos

Nanophthalmia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05116	FRZB Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19333	Frzb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25824	Frzb Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	FRZB	VGNC	VGNC:62372
Rattus norvegicus	FRZB	RGD	RGD:1311315
Mus musculus	FRZB	MGD	MGI:892032
Bos taurus	FRZB	VGNC	VGNC:29124
Macaca mulatta	FRZB	VGNC	VGNC:72819
Canis familiaris	FRZB	VGNC	VGNC:53094
Others	FRZB	NCBI

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