2. Gene
  3. Plp1 - proteolipid protein 1 Gene

Plp1 - proteolipid protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Plp

基因 ID: 24943 | 基因类型: protein coding

关于 Plp1

功能概要

A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in myelin sheath. Part of Integrin alphav-beta3 complex. Used to study demyelinating disease and visual epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Plp1 基因产物(1)

mRNA Protein Name
NM_030990.3 NP_112252.1 myelin proteolipid protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
16510724 RGD
enables structural constituent of myelin sheath IMP
IMP: 通过突变表型推断
3476944 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in AMPA selective glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
16510724 RGD
involved in glial cell differentiation IMP
IMP: 通过突变表型推断
1384273 RGD
involved in myelination IMP
IMP: 通过突变表型推断
3476944 RGD
involved in positive regulation of calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
16510724 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
16510724 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of integrin alphav-beta3 complex IDA
IDA: 通过直接分析推断
16510724 RGD
located in myelin sheath IDA
IDA: 通过直接分析推断
17960831 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

myelin proteolipid protein

Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)

lipophilin

proteolipid protein (myelin) 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128749A D-Glucaric acid tetrahydrate Inducer 98.0% 否
HY-RS10731 PLP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18783 Plp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25272 Plp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plp1 NCBI NCBI:5354
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