2. Gene
  3. Srd5a1 - steroid 5 alpha-reductase 1 Gene

Srd5a1 - steroid 5 alpha-reductase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: S5AR 1

基因 ID: 24950 | 基因类型: protein coding

关于 Srd5a1

功能概要

Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including animal organ development; cellular hormone metabolic process; and cellular response to organic cyclic compound. Located in several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate Cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate Cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1). [provided by Alliance of Genome Resources, Apr 2022]

Srd5a1 基因产物(1)

mRNA Protein Name
NM_017070.3 NP_058766.2 3-oxo-5-alpha-steroid 4-dehydrogenase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IDA
IDA: 通过直接分析推断
7482629 RGD
enables NADPH binding IDA
IDA: 通过直接分析推断
11377984 RGD
enables amide binding IDA
IDA: 通过直接分析推断
9090798 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in androgen biosynthetic process IDA
IDA: 通过直接分析推断
12606426 RGD
involved in androgen catabolic process IDA
IDA: 通过直接分析推断
2339109 RGD
involved in androgen metabolic process IDA
IDA: 通过直接分析推断
20954080 RGD
involved in bone development IEP
IEP: 通过表达模式推断
15012600 RGD
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
14997014 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
15004407 RGD
involved in cellular response to epinephrine stimulus IEP
IEP: 通过表达模式推断
14997014 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
15312799 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
15249139 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
20810561 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
15936112 RGD
involved in cellular response to starvation IEP
IEP: 通过表达模式推断
9729333 RGD
involved in cellular response to testosterone stimulus IEP
IEP: 通过表达模式推断
15004407 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
8770891 RGD
involved in diterpenoid metabolic process IEP
IEP: 通过表达模式推断
14997014 RGD
involved in female genitalia development IEP
IEP: 通过表达模式推断
9142501 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
8770891 RGD
involved in hypothalamus development IEP
IEP: 通过表达模式推断
8770891 RGD
involved in liver development IEP
IEP: 通过表达模式推断
8770891 RGD
involved in male genitalia development IEP
IEP: 通过表达模式推断
9142501 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
12606426 RGD
involved in pituitary gland development IEP
IEP: 通过表达模式推断
8770891 RGD
involved in progesterone metabolic process IDA
IDA: 通过直接分析推断
9202401 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
9504773 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
19793540 RGD
involved in response to follicle-stimulating hormone IEP
IEP: 通过表达模式推断
12630924 RGD
involved in response to fungicide IEP
IEP: 通过表达模式推断
19728174 RGD
involved in response to growth hormone IEP
IEP: 通过表达模式推断
10067850 RGD
involved in response to muscle activity IEP
IEP: 通过表达模式推断
20045012 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17940878 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
16595696 RGD
involved in response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
1314830 RGD
involved in serotonin metabolic process IEP
IEP: 通过表达模式推断
15936112 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
8770891 RGD
involved in steroid biosynthetic process IDA
IDA: 通过直接分析推断
7482629 RGD
involved in thalamus development IEP
IEP: 通过表达模式推断
8770891 RGD
involved in urogenital system development IEP
IEP: 通过表达模式推断
8584033 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body fiber IDA
IDA: 通过直接分析推断
15305365 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15305365 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
7553073 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

3-oxo-5-alpha-steroid 4-dehydrogenase 1

SR type 1

steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-19292 AS-601811 Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-152094 SRD5A1-IN-1 Inhibitor 99.82% 否
HY-RS13754 SRD5A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19076 Srd5a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25567 Srd5a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Srd5a1 NCBI NCBI:6715
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