2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase
  4. SRD5A1-IN-2

SRD5A1-IN-2 是一种类固醇 5α-还原酶类型 1 (SRD5A1) 抑制剂，IC50 为 8.5 μM。SRD5A1-IN-2 下调 HaCaT 细胞中 SRD5A1 蛋白的表达。SRD5A1-IN-2 降低 HaCaT 细胞中二氢睾酮 (DHT) 的生成。SRD5A1-IN-2 可用于研究雄激素相关疾病，如雄激素性脱发 (AGA)。

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SRD5A1-IN-2

SRD5A1-IN-2 Chemical Structure

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SRD5A1-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SRD5A1-IN-2 is a inhibitor of steroid 5α-reductase type-1 (SRD5A1), with an IC50 of 8.5 μM. SRD5A1-IN-2 downregulates SRD5A1 protein expression in HaCaT cells. SRD5A1-IN-2 reduces dihydrotestosterone (DHT) production in HaCaT cells. SRD5A1-IN-2 can be used for the study of androgen-related conditions such as androgenetic alopecia (AGA)[1].

IC50 & Target[1]

SRD5A1

8.5 μM (IC50)

体外研究
(In Vitro)

SRD5A1-IN-2 (Compound 10a) 在 HaCaT 细胞中表现出细胞毒性，半数致死浓度 (LC50) 为 21.31 μM[1]。
SRD5A1-IN-2 (10 μM, 24 h) 抑制 HaCaT 细胞中类固醇 5α-还原酶类型 1 (SRD5A1) 活性，IC50 为 8.5 μM，并降低二氢睾酮 (DHT) 生成[1]。
SRD5A1-IN-2 (2.5-15 μM, 24 h) 显著下调 HaCaT 细胞中 SRD5A1 蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SRD5A1-IN-2 相关抗体:

Cell Viability Assay[1]

Cell Line: HaCaT cells
Concentration: 2.5, 5, 10, 15 μM
Incubation Time: 24 h
Result: Downregulated SRD5A1 protein expression in HaCaT cells.
分子量

406.28

Formula

C18H12F6O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SRD5A1-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRD5A1-IN-25 alpha Reductase5α-reductaseandrogenetic alopeciaandrogensteroid 5α-reductase type-1Inhibitorinhibitorinhibit

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