2. Gene
  3. Fyn - FYN proto-oncogene, Src family tyrosine kinase Gene

Fyn - FYN proto-oncogene, Src family tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 25150 | 基因类型: protein coding

关于 Fyn

功能概要

Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of cell death; and protein phosphorylation. Located in several cellular components, including mitochondrion; perinuclear endoplasmic reticulum; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human Fyn (Fyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fyn 基因产物(1)

mRNA Protein Name
NM_012755.2 NP_036887.1 tyrosine-protein kinase Fyn
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CD4 receptor binding IPI
IPI: 通过物理相互作用推断
1372996 RGD
enables CD8 receptor binding IPI
IPI: 通过物理相互作用推断
1372996 RGD
enables T cell receptor binding IDA
IDA: 通过直接分析推断
1372996 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
12231245 RGD
enables peptide hormone receptor binding IPI
IPI: 通过物理相互作用推断
7935483 RGD
enables phosphatidylinositol 3-kinase binding IDA
IDA: 通过直接分析推断
9460655 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8103744 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
12353920 RGD
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
8870703 RGD
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
17526495 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
12618293 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
1280324 RGD
enables type 5 metabotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
24012003 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to L-glutamate IMP
IMP: 通过突变表型推断
17526495 RGD
involved in cellular response to glycine IMP
IMP: 通过突变表型推断
17526495 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
11236902 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
27525436 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
9460655 RGD
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
18469807 RGD
involved in negative regulation of hydrogen peroxide biosynthetic process IMP
IMP: 通过突变表型推断
27525436 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
18469807 RGD
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
27525436 RGD
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
9460655 RGD
involved in peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
12231245 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
18469807 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
12353920 RGD
involved in response to singlet oxygen IDA
IDA: 通过直接分析推断
27525436 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
9551931 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in dendrite IDA
IDA: 通过直接分析推断
24012003 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
27457929 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
27525436 RGD
located in nucleus IDA
IDA: 通过直接分析推断
27525436 RGD
located in perinuclear endoplasmic reticulum IDA
IDA: 通过直接分析推断
27525436 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
27525436 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
22820466 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
27457929 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase Fyn

FYN oncogene related to SRC, FGR, YES

p59-Fyn

proto-oncogene c-Fyn

proto-oncogene tyrosine-protein kinase Fyn

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-157442 GLPG3312 Inhibitor 98.57% Phase 1
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-118105 RK-20448 Inhibitor 99.38% 否
HY-176194 Antifibrotic agent 1 Inhibitor / 否
HY-120622 BMS-243117 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fyn NCBI NCBI:2534
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z