2. Gene
  3. Aqp4 - aquaporin 4 Gene

Aqp4 - aquaporin 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Miwc; WCH4; AQP-4

基因 ID: 25293 | 基因类型: protein coding

关于 Aqp4

功能概要

This gene encodes a member of the Aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant Aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]

Aqp4 基因产物(5)

mRNA Protein Name
NM_001142366.2 NP_001135838.1 aquaporin-4 isoform M23
NM_001270558.2 NP_001257487.1 aquaporin-4 isoform 3
NM_001270559.2 NP_001257488.1 aquaporin-4 isoform 4
NM_001317749.1 NP_001304678.1 aquaporin-4 isoform M1x
NM_012825.4 NP_036957.1 aquaporin-4 isoform M1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16650285 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
21262839 RGD
enables water channel activity IDA
IDA: 通过直接分析推断
7528931 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carbon dioxide transport IDA
IDA: 通过直接分析推断
19273840 RGD
involved in cell-cell adhesion IMP
IMP: 通过突变表型推断
16325200 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
21471464 RGD
involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
22449442 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
22449442 RGD
involved in cellular response to interleukin-6 IEP
IEP: 通过表达模式推断
22449442 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
18579859 RGD
involved in intracellular water homeostasis IDA
IDA: 通过直接分析推断
21251984 RGD
involved in negative regulation of cell adhesion molecule production IMP
IMP: 通过突变表型推断
22449442 RGD
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
22449442 RGD
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
22449442 RGD
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
16325200 RGD
involved in regulation of vascular endothelial growth factor production IMP
IMP: 通过突变表型推断
22449442 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
21724913 RGD
involved in water transport IDA
IDA: 通过直接分析推断
7528931 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
20849844 RGD
located in astrocyte end-foot IDA
IDA: 通过直接分析推断
29055082 RGD
located in basal plasma membrane IDA
IDA: 通过直接分析推断
9875338 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
9875338 RGD
located in cell projection membrane IDA
IDA: 通过直接分析推断
9875338 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
16325200 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
20153404 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
20849844 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aquaporin-4

mercurial-insensitive water channel

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-115460 AER-271 96.90% Phase 1
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W008574 TGN-020 99.97% 否
HY-W008574A TGN-020 sodium 99.96% 否
HY-W176557 TGN-073 99.53% 否
HY-P10936A AQP4 (201-220) TFA 98.01% 否
HY-N10756 Hyp9 Agonist 99.90% 否
HY-RS00876 AQP4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-157226 ORI-TRN-002 Inhibitor / 否
HY-P10936 AQP4 (201-220) / 否
HY-P10937 AQP4 (205-215) / 否
HY-P10937A AQP4 (205-215) TFA / 否
HY-RS16702 Aqp4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23136 Aqp4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aqp4 NCBI NCBI:361
Mus musculus Aqp4 NCBI NCBI:11829
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