2. Gene
  3. Dcc - DCC netrin 1 receptor Gene

Dcc - DCC netrin 1 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 25311 | 基因类型: protein coding

关于 Dcc

功能概要

Enables identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; and response to amphetamine. Located in growth cone membrane and membrane raft. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Dcc 基因产物(1)

mRNA Protein Name
NM_012841.2 NP_036973.1 netrin receptor DCC precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18585357 RGD
enables netrin receptor activity IMP
IMP: 通过突变表型推断
8861902 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15788770 RGD
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
12840034 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in axon guidance IMP
IMP: 通过突变表型推断
8861902 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in corpus callosum development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in optic nerve development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
15811950 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
15737744 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
17996376 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
12840034 RGD
located in growth cone membrane IDA
IDA: 通过直接分析推断
18691385 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

netrin receptor DCC

colorectal tumor suppressor

deleted in colorectal carcinoma

putative colorectal tumor suppressor

tumor suppressor protein DCC

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-112306 Ripretinib 98.90% 是
HY-136256 Vimseltinib Inhibitor 99.94% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-13024 Rebastinib 99.91% Phase 2
HY-160699 DCC-3116 Inhibitor 99.25% Phase 2
HY-B0791 Altiratinib Inhibitor 99.29% Phase 1
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-Y1092 N,N-Dicyclohexylcarbodiimide(DCC) Activator 99.75% 否
HY-W074890 Palmitoylglycine Modulator 99.84% 否
HY-W099632 2-Hexyldecanoic acid 99.71% 否
HY-100855 DC_C66 Inhibitor / 否
HY-157262 Methyl isonicotinate-(CH2)2-COOH / 否
HY-163008 Dicamba-5-aminopentanoic acid / 否
HY-RS03571 DCC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-D2751 BP Fluor 488 cadaverine / 否
HY-D2764 Difluorocarboxyfluorescein cadaverine, 5-isomer / 否
HY-D2765 BP Fluor 405 cadaverine / 否
HY-D2772 5-TAMRA Cadaverine / 否
HY-RS17183 Dcc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23634 Dcc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dcc NCBI NCBI:1630
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