2. Gene
  3. Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Mgmt - O-6-methylguanine-DNA methyltransferase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：O-6-甲基鸟嘌呤-DNA 甲基转移酶

种属: Rattus norvegicus

基因 ID: 25332 | 基因类型: protein coding

关于 Mgmt

Primary_assembly 1: 191,710,930-191,937,756 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 189 orthologues and is associated with 31 phenotypes. Biased expression in Liver (RPKM 16.5), Spleen (RPKM 119.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动钙离子结合活性和甲基化 DNA-[蛋白质]-半胱氨酸 S-甲基转移酶活性。涉及多个过程，包括参与 DNA 修复的 DNA 脱烷基化；细胞对电离辐射的反应；和对叶酸的反应。位于核内。结肠腺癌和黑色素瘤的生物标志物。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；内分泌腺癌（多发）；颗粒细胞瘤；神经系统癌症（多发性）；和膀胱癌。与人类 MGMT（O-6-甲基鸟嘌呤-DNA 甲基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA dealkylation involved in DNA repair; cellular response to ionizing radiation; and response to folic acid. Located in nucleus. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt 基因产物(2)

mRNA Protein Name
NM_012861.1 NP_036993.1 methylated-DNA--protein-cysteine methyltransferase
NM_012861.1 NP_036993.1 methylated-DNA--protein-cysteine methyltransferase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
12479403 RGD
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
IDA: 通过直接分析推断
15025514 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA alkylation repair IDA
IDA: 通过直接分析推断
15025514 RGD
involved in DNA damage response IEP
IEP: 通过表达模式推断
12815001 RGD
involved in cellular response to ionizing radiation IEP
IEP: 通过表达模式推断
9780001 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
19549930 RGD
involved in cellular response to oxidative stress IEP
IEP: 通过表达模式推断
11133343 RGD
involved in mammary gland epithelial cell differentiation IEP
IEP: 通过表达模式推断
16086375 RGD
involved in positive regulation of DNA repair IDA
IDA: 通过直接分析推断
1945835 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
11524300 RGD
involved in response to folic acid IEP
IEP: 通过表达模式推断
20051376 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
12517412 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
20011461 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19860839 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mgmt 蛋白结构

AdaB

AdaB: COG0350 (5 - 177)

  • 0
  • 100
  • 209 a.a.
蛋白主名 其他名称

methylated-DNA--protein-cysteine methyltransferase

0-6-methylguanine-DNA methyltransferase

6-O-methylguanine-DNA methyltransferase

O(6)-alkylguanine-DNA alkyltransferase

O-6-methylguanine-DNA-alkyltransferase

O6-alkylguanine-DNA alkyltransferase

O6-methylguanine-DNA methyltranferase

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13668 Lomeguatrib Inhibitor 99.77% Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13057 O6BTG-octylglucoside Inhibitor 95.0% 否
HY-175299 Hedgehog IN-11 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mgmt NCBI NCBI:4255
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