2. Gene
  3. Anxa1 - annexin A1 Gene

Anxa1 - annexin A1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: p35; Anx1

基因 ID: 25380 | 基因类型: protein coding

关于 Anxa1

功能概要

Enables several functions, including DNA/DNA annealing activity; double-stranded DNA helicase activity; and Phospholipase A2 inhibitor activity. Contributes to single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in several processes, including estrous cycle; gland development; and peptide hormone secretion. Located in several cellular components, including extracellular space; mast cell granule; and mitochondrial membrane. Part of protein-containing complex. Is active in synaptic membrane. Used to study acute kidney failure; brain ischemia; pleurisy; and uveitis. Biomarker of several diseases, including carcinoma (multiple); cerebral infarction; eye disease (multiple); hyperthyroidism; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic Cancer. Orthologous to human ANXA1 (annexin A1). [provided by Alliance of Genome Resources, Apr 2022]

Anxa1 基因产物(1)

mRNA Protein Name
NM_012904.2 NP_037036.1 annexin A1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA/DNA annealing activity IDA
IDA: 通过直接分析推断
20655937 RGD
enables double-stranded DNA helicase activity IDA
IDA: 通过直接分析推断
20655937 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8335093 RGD
enables phospholipase A2 inhibitor activity IDA
IDA: 通过直接分析推断
2969352 RGD
enables phospholipid binding IDA
IDA: 通过直接分析推断
17993484 RGD
contributes to single-stranded DNA binding IDA
IDA: 通过直接分析推断
10548514 RGD
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
20655937 RGD
contributes to single-stranded RNA binding IDA
IDA: 通过直接分析推断
10548514 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA duplex unwinding IDA
IDA: 通过直接分析推断
20655937 RGD
involved in cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
12459455 RGD
involved in cellular response to glucocorticoid stimulus IDA
IDA: 通过直接分析推断
2936963 RGD
involved in cellular response to hydrogen peroxide IMP
IMP: 通过突变表型推断
8607818 RGD
involved in endocrine pancreas development IEP
IEP: 通过表达模式推断
7527053 RGD
involved in estrous cycle IEP
IEP: 通过表达模式推断
17283243 RGD
involved in gliogenesis IEP
IEP: 通过表达模式推断
9263577 RGD
involved in hepatocyte differentiation IEP
IEP: 通过表达模式推断
11668598 RGD
involved in insulin secretion IDA
IDA: 通过直接分析推断
12459455 RGD
involved in negative regulation of phospholipase A2 activity IDA
IDA: 通过直接分析推断
2969352 RGD
involved in negative regulation of protein secretion IMP
IMP: 通过突变表型推断
8559285 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
8607818 RGD
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: 通过突变表型推断
8260938 RGD
involved in prolactin secretion IMP
IMP: 通过突变表型推断
10830310 RGD
involved in prostate gland development IEP
IEP: 通过表达模式推断
22911278 RGD
involved in response to X-ray IEP
IEP: 通过表达模式推断
9269316 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
17283243 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
17283243 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
9022675 RGD
involved in response to interleukin-1 IEP
IEP: 通过表达模式推断
11311405 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
8300854 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
8828496 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
9416328 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
10489933 RGD
located in mast cell granule IDA
IDA: 通过直接分析推断
11005211 RGD
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
10806526 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
10548514 RGD
is active in synaptic membrane IDA
IDA: 通过直接分析推断
8335093 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

annexin A1

Annexin 1 (p35) (Lipocortin 1)

annexin I

annexin-1

calpactin II

calpactin-2

chromobindin-9

lipocortin 1

lipocortin I

phospholipase A2 inhibitory protein

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10412 A11 98.49% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Anxa1 NCBI NCBI:301
Macaca fascicularis Anxa1 NCBI NCBI:102144835
Canis lupus familiaris Anxa1 NCBI
Mus musculus Anxa1 NCBI NCBI:16952
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