2. Gene
  3. Col2a1 - collagen type II alpha 1 chain Gene

Col2a1 - collagen type II alpha 1 chain Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: CG2A1A; COLLII

基因 ID: 25412 | 基因类型: protein coding

关于 Col2a1

功能概要

Predicted to enable several functions, including MHC class II protein binding activity; identical protein binding activity; and platelet-derived growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cartilage development; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Located in collagen-containing extracellular matrix and cytoplasm. Used to study degenerative disc disease; hypothyroidism; and osteoarthritis. Biomarker of degenerative disc disease and osteonecrosis. Human ortholog(s) of this gene implicated in Stickler syndrome (multiple); bone disease (multiple); cleft palate; eye disease (multiple); and multiple epiphyseal dysplasia with myopia and deafness. Orthologous to human COL2A1 (Collagen type II alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col2a1 基因产物(3)

mRNA Protein Name
NM_001414896.1 NP_001401825.1 collagen alpha-1(II) chain isoform 1 precursor
NM_012929.2 NP_037061.2 collagen alpha-1(II) chain isoform 2 precursor
NM_012929.1 NP_037061.1 collagen alpha-1(II) chain precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cartilage development IEP
IEP: 通过表达模式推断
9822201 RGD
involved in cartilage development involved in endochondral bone morphogenesis IEP
IEP: 通过表达模式推断
12924823 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: 通过表达模式推断
18595745 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19725071 RGD
involved in cellular response to nicotine IEP
IEP: 通过表达模式推断
22766705 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: 通过表达模式推断
22750004 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
11120880 RGD
involved in cellular response to retinoic acid IEP
IEP: 通过表达模式推断
23810783 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
19144181 RGD
involved in cellular response to vitamin E IEP
IEP: 通过表达模式推断
23722449 RGD
involved in chondrocyte differentiation IEP
IEP: 通过表达模式推断
21627568 RGD
involved in growth plate cartilage development IEP
IEP: 通过表达模式推断
20591638 RGD
involved in response to X-ray IEP
IEP: 通过表达模式推断
17549535 RGD
involved in response to fibroblast growth factor IEP
IEP: 通过表达模式推断
21147086 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
19242967 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
7649371 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

collagen alpha-1(II) chain

Procollagen II alpha 1

alpha-1 type II collagen

collagen type II (Col2A1) gene, enhancer region

collagen, type II, alpha 1

procollagen, type II, alpha 1

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108065A 3'-Sialyllactose sodium Inhibitor ≥98.0% 否
HY-RS02981 COL2A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-108065 3'-Sialyllactose Inhibitor / 否
HY-RS18559 Col2a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25041 Col2a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Col2a1 NCBI NCBI:1280
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