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  4. 3'-Sialyllactose sodium

3'-Sialyllactose sodium  (Synonyms: 3'-SL sodium)

目录号: HY-108065A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

3'-Sialyllactose (3'-SL) sodium 是一种益生元，具有维持免疫稳态，发挥抗炎和抗关节炎的作用。3'-Sialyllactose sodium 是毒性等级最低的普通碳水化合物，可用于炎症的研究。

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3'-Sialyllactose sodium Chemical Structure

3'-Sialyllactose sodium Chemical Structure

CAS No. : 128596-80-5

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规格 价格 是否有货 数量
5 mg ￥400
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10 mg ￥700
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Customer Review

Other Forms of 3'-Sialyllactose sodium:

3'-Sialyllactose sodium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2][3].

体外研究
(In Vitro)

3'-Sialyllactose sodium (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].
3'-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1].
3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[3].
3'-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3'-Sialyllactose sodium 相关抗体:

Western Blot Analysis[1]

Cell Line: Chondrocytes
Concentration: 0, 50, 100 and 250 μM
Incubation Time: 24-36 hours
Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.
体内研究
(In Vivo)

3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].
3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice[3].
3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3].
3'-Sialyllactose sodium shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1]
Dosage: 10, 50 and 100 mg/kg
Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks
Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.
分子量

655.53

Formula

C23H38NNaO19
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 250 mg/mL (381.37 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5255 mL 7.6274 mL 15.2548 mL
5 mM 0.3051 mL 1.5255 mL 3.0510 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

3'-Sialyllactose sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5255 mL 7.6274 mL 15.2548 mL 38.1371 mL
5 mM 0.3051 mL 1.5255 mL 3.0510 mL 7.6274 mL
10 mM 0.1525 mL 0.7627 mL 1.5255 mL 3.8137 mL
15 mM 0.1017 mL 0.5085 mL 1.0170 mL 2.5425 mL
20 mM 0.0763 mL 0.3814 mL 0.7627 mL 1.9069 mL
25 mM 0.0610 mL 0.3051 mL 0.6102 mL 1.5255 mL
30 mM 0.0508 mL 0.2542 mL 0.5085 mL 1.2712 mL
40 mM 0.0381 mL 0.1907 mL 0.3814 mL 0.9534 mL
50 mM 0.0305 mL 0.1525 mL 0.3051 mL 0.7627 mL
60 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.6356 mL
80 mM 0.0191 mL 0.0953 mL 0.1907 mL 0.4767 mL
100 mM 0.0153 mL 0.0763 mL 0.1525 mL 0.3814 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3'-Sialyllactose128596-80-53'-SLNF-κBNuclear factor-κBNuclear factor-kappaBpolysaccharideprebiotichomeostasisinflammationimmuneCol2a1osteoarthritismiceInhibitorinhibitorinhibit

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