2. Gene
  3. Agrn - agrin Gene

Agrn - agrin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: AGR

基因 ID: 25592 | 基因类型: protein coding

关于 Agrn

功能概要

Enables calcium ion binding activity; cytokine binding activity; and dystroglycan binding activity. Involved in several processes, including positive regulation of filopodium assembly; positive regulation of nitrogen compound metabolic process; and synapse organization. Acts upstream of or within receptor clustering. Located in axonal growth cone; basement membrane; and synapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Apr 2022]

Agrn 基因产物(1)

mRNA Protein Name
NM_175754.2 NP_786930.2 agrin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BMP binding IPI
IPI: 通过物理相互作用推断
20505824 RGD
enables calcium ion binding IDA
IDA: 通过直接分析推断
20566625 RGD
enables dystroglycan binding IDA
IDA: 通过直接分析推断
8693000 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8205617 RGD
enables transforming growth factor beta binding IPI
IPI: 通过物理相互作用推断
20505824 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chemical synaptic transmission IMP
IMP: 通过突变表型推断
15883200 RGD
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
20471381 RGD
involved in positive regulation of filopodium assembly IDA
IDA: 通过直接分析推断
20471381 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
18957220 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
22302937 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12796478 RGD
acts upstream of or within receptor clustering IDA
IDA: 通过直接分析推断
15155732 RGD
involved in regulation of axon guidance IDA
IDA: 通过直接分析推断
17870250 RGD
involved in regulation of microtubule cytoskeleton organization IDA
IDA: 通过直接分析推断
17870250 RGD
involved in regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
18848351 RGD
involved in regulation of synapse organization IDA
IDA: 通过直接分析推断
19524020 RGD
involved in regulation of synapse organization IMP
IMP: 通过突变表型推断
19524020 RGD
involved in skeletal muscle acetylcholine-gated channel clustering IDA
IDA: 通过直接分析推断
18957220 RGD
involved in skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
22302937 RGD
involved in synapse assembly IMP
IMP: 通过突变表型推断
12486121 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axonal growth cone IDA
IDA: 通过直接分析推断
14697677 RGD
located in basement membrane IDA
IDA: 通过直接分析推断
15711988 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
19524020 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
19524020 RGD
located in synapse IDA
IDA: 通过直接分析推断
12796478 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

agrin

Agrn 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Agrn P25304 Lrp4 Mus musculus Q8VI56
Pull Down
18848351
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00464 AGRN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19873 Agrn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26372 Agrn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Agrn NCBI NCBI:375790
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