2. Gene
  3. DPCD - deleted in primary ciliary dyskinesia homolog (mouse) Gene

DPCD - deleted in primary ciliary dyskinesia homolog (mouse) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：在原发性纤毛运动障碍同系物 (小鼠) 中缺失

种属: Homo sapiens

基因 ID: 25911 | 基因类型: protein coding

关于 DPCD

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,588,321-101,609,662 (from NCBI)

This gene has 6 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 51.1), kidney (RPKM 13.2) and 19 other tissues.

功能概要

小鼠中的该基因编码一种可能参与纤毛细胞生成和维持的蛋白质。在小鼠中，该基因的表达在纤毛细胞分化过程中增加，并且该基因的破坏与原发性纤毛运动障碍有关。[RefSeq 提供，2016 年 7 月]

This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]

DPCD 基因产物(6)

mRNA Protein Name
NM_001329742.2 NP_001316671.1 protein DPCD isoform 1
NM_001329743.2 NP_001316672.1 protein DPCD isoform 3
NM_001329744.2 NP_001316673.1 protein DPCD isoform 4
NM_001329745.2 NP_001316674.1 protein DPCD isoform 5
NM_001329746.2 NP_001316675.1 protein DPCD isoform 6
NM_015448.3 NP_056263.1 protein DPCD isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DPCD 蛋白结构

DPCD

DPCD: DPCD protein family (6 - 197)

  • 0
  • 100
  • 203 a.a.
蛋白主名 其他名称

protein DPCD

RP11-529I10.4

DPCD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Validated Y2H
32296183
种属内
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Validated Y2H
25416956
种属内
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Y2H Prey Pooling
32296183
种属内
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pulmonary Subvalvular Stenosis

Pulmonary Infundibular Stenosis

Congenital Infundibular Stenosis

Infundibular Pulmonic Stenosis

Infundibular Pulmonic Stenosis, Congenital

Subvalvular Pulmonic Stenosis
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Intellectual Developmental Disorder, Autosomal Dominant 29

MRD29

Autosomal Dominant Non-Syndromic Intellectual Disability 29

Mental Retardation, Autosomal Dominant 29

Autosomal Dominant Intellectual Developmental Disorder 29

Autosomal Dominant Mental Retardation 29

Mental Retardation, Autosomal Dominant, Type 29
Brachydactyly, Type A2

Brachydactyly Type A2

BDA2

Mohr-Wriedt Type Brachydactyly

Brachymesophalangy Ii

Brachymesophalangy Type 2

Brachymesophalangy 2

Brachydactyly, Mohr-Wriedt Type

Brachydactyly A2
Intellectual Developmental Disorder, Autosomal Dominant 5

MRD5

Autosomal Dominant Non-Syndromic Intellectual Disability 5

Intellectual Disability, Autosomal Dominant 5

Mental Retardation, Autosomal Dominant 5

Autosomal Dominant Intellectual Developmental Disorder 5

Syngap1-Related Non-Syndromic Intellectual Disability

Autosomal Dominant Intellectual Disability 5

Syngap1 Syndrome

Syngap1-Related Nsid

Syngap1 Gene Mutation Linked To Intellectual Disability, Schizophrenia And Autism
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1

PKD1

Adpkd

Polycystic Kidney Disease, Adult, Type I

Apkd1

Potter Type Iii Polycystic Kidney Disease

Polycystic Kidney Disease, Adult

Potter Type Iii Polycystic Kidney Disease, Formerly

Polycystic Kidney Disease, Type 1

Adpkd1

Adult Polycystic Kidney Disease Type 1

Autosomal Dominant Polycystic Kidney Disease 1

Pkd-1

Polycystic Kidney Disease Adult

Polycystic Kidney Disease Type I

Polycystic Kidneys

Polycystic Kidney Disease, Adult Type I

Polycystic Kidney Type 1 Autosomal Dominant Disease

Kidney Disease, Polycystic, Type 1

Polycystic Kidney, Autosomal Dominant

Polycystic Kidney, Type 1 Autosomal Dominant Disease

Polycystic Kidney Diseases
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03946 DPCD Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DPCD MGD MGI:1924407
Rattus norvegicus DPCD RGD RGD:1307648
Macaca mulatta DPCD VGNC VGNC:106036
Canis familiaris DPCD VGNC VGNC:56112
Bos taurus DPCD VGNC VGNC:55947
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