2. Gene
  3. IL4I1 - interleukin 4 induced 1 Gene

IL4I1 - interleukin 4 induced 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白介素 4 诱导 1

种属: Homo sapiens

同用名: LAO; FIG1; LAAO; hIL4I1

基因 ID: 259307 | 基因类型: protein coding

关于 IL4I1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,889,654-49,929,504 (from NCBI)

This gene has 8 transcripts (splice variants), 325 orthologues and 7 paralogues. Broad expression in testis (RPKM 12.4), liver (RPKM 8.9) and 22 other tissues.

功能概要

该基因编码一种分泌型 L-氨基酸氧化酶蛋白，该蛋白主要分解代谢 L-苯丙氨酸，并在较小程度上分解代谢 L-精氨酸。该基因的表达由 B 细胞中的细胞因子白细胞介素 4 诱导。该基因也在巨噬细胞和树突细胞中表达。这种蛋白质可能在免疫系统逃逸中发挥作用，因为它在肿瘤相关巨噬细胞中表达并抑制 T 细胞反应。该蛋白质还包含被认为与黄素腺嘌呤二核苷酸 (FAD) 辅助因子结合有关的结构域。已发现该基因编码不同异构体的多个转录变体。该基因的一些转录本与重叠的 NUP62 基因共享 5' UTR 的启动子和外显子。[RefSeq 提供，2020 年 7 月]

This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020]

IL4I1 基因产物(5)

mRNA Protein Name
NM_001258017.2 NP_001244946.1 L-amino-acid oxidase isoform 2 precursor
NM_001258018.2 NP_001244947.1 L-amino-acid oxidase isoform 2 precursor
NM_001385639.1 NP_001372568.1 L-amino-acid oxidase isoform 3 precursor
NM_152899.2 NP_690863.1 L-amino-acid oxidase isoform 1 precursor
NM_172374.3 NP_758962.1 L-amino-acid oxidase isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-amino-acid oxidase activity IDA
IDA: 通过直接分析推断
17356132 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-phenylalanine catabolic process IDA
IDA: 通过直接分析推断
17356132 GOA
involved in negative regulation of T cell activation IDA
IDA: 通过直接分析推断
28891065 GOA
involved in negative regulation of T cell mediated immune response to tumor cell IDA
IDA: 通过直接分析推断
32818467 GOA
involved in negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
17356132 GOA
involved in positive regulation of regulatory T cell differentiation IDA
IDA: 通过直接分析推断
25778793 GOA
acts upstream of positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
32818467 GOA
involved in regulation of adaptive immune response IDA
IDA: 通过直接分析推断
17356132 GOA
involved in tryptophan catabolic process IDA
IDA: 通过直接分析推断
17356132 GOA
involved in tryptophan catabolic process to indole-3-acetate IDA
IDA: 通过直接分析推断
32818467 GOA
involved in tyrosine catabolic process IDA
IDA: 通过直接分析推断
17356132 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in acrosomal vesicle IDA
IDA: 通过直接分析推断
25767141 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
17356132 GOA
located in immunological synapse IDA
IDA: 通过直接分析推断
28891065 GOA
located in sperm midpiece IDA
IDA: 通过直接分析推断
25767141 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL4I1 蛋白结构

Amino_oxidase

Amino_oxidase: Flavin containing amine oxidoreductase (69 - 504)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 567 a.a.
蛋白主名 其他名称

L-amino-acid oxidase

Fig-1 protein

IL4I1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL4I1 Q96RQ9 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
IL4I1 Q96RQ9 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
IL4I1 Q96RQ9 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
IL4I1 Q96RQ9 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
种属内
IL4I1 Q96RQ9 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
种属内
IL4I1 Q96RQ9 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

IL4I1 抗体

目录号 产品名 应用 反应物种
HY-P81480 IL-4I1/LAO Antibody (YA1225) IHC-P Human

关联疾病

疾病名称 别名
Striatonigral Degeneration, Infantile

Infantile Bilateral Striatal Necrosis

Ibsn

SNDI

Striatonigral Degeneration Infantile

Infantile Striatonigral Degeneration

Bilateral Striatal Necrosis, Infantile

Striatal Degeneration, Familial

Striatal Degeneration Familial

Infantile Striatonigral Necrosis

Familial Striatal Degeneration
Primary Mediastinal Large B-Cell Lymphoma

Mediastinal Large B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Med-Dlbcl

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Mediastinal Large B-Cell Lymphoma
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
Gas Gangrene

Myonecrosis

Gas Bacillus Infection

Gas Gangrene Due To Clostridia

Clostridial Myonecrosis

Clostridial Cellulitis
Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma
Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-174262 IL4I1-IN-1 Inhibitor 99.26% 否
HY-RS06768 IL4I1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17465 Il4i1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23923 Il4i1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris IL4I1 VGNC VGNC:41988
Felis catus IL4I1 VGNC VGNC:62914
Mus musculus IL4I1 MGD MGI:109552
Macaca mulatta IL4I1 VGNC VGNC:73625
Rattus norvegicus IL4I1 RGD RGD:1304831
Bos taurus IL4I1 VGNC VGNC:30162
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