2. Gene
  3. TPGS2 - tubulin polyglutamylase complex subunit 2 Gene

TPGS2 - tubulin polyglutamylase complex subunit 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管蛋白聚谷氨酰胺酶复合亚基 2

种属: Homo sapiens

同用名: L17; PGs2; C18orf10; HMFN0601

基因 ID: 25941 | 基因类型: protein coding

关于 TPGS2

This gene has 21 transcripts (splice variants) and 227 orthologues. Broad expression in testis (RPKM 16.4), brain (RPKM 5.6) and 24 other tissues.

功能概要

该基因编码的蛋白质是神经元聚谷氨酰胺酶复合物的一个组成部分，它在翻译后将谷氨酸残基添加到 C 末端微管蛋白尾部中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

TPGS2 基因产物(10)

mRNA Protein Name
NM_001271949.2 NP_001258878.1 tubulin polyglutamylase complex subunit 2 isoform 2
NM_001271950.2 NP_001258879.1 tubulin polyglutamylase complex subunit 2 isoform 3
NM_001271951.2 NP_001258880.1 tubulin polyglutamylase complex subunit 2 isoform 4
NM_001271952.2 NP_001258881.1 tubulin polyglutamylase complex subunit 2 isoform 5
NM_001271953.2 NP_001258882.1 tubulin polyglutamylase complex subunit 2 isoform 6
NM_001271954.2 NP_001258883.1 tubulin polyglutamylase complex subunit 2 isoform 7
NM_001271955.2 NP_001258884.1 tubulin polyglutamylase complex subunit 2 isoform 8
NM_001271956.2 NP_001258885.1 tubulin polyglutamylase complex subunit 2 isoform 9
NM_001330572.2 NP_001317501.1 tubulin polyglutamylase complex subunit 2 isoform 10
NM_015476.4 NP_056291.2 tubulin polyglutamylase complex subunit 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tubulin polyglutamylase complex subunit 2

polyglutamylase subunit 2

TPGS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TPGS2 Q68CL5 OTP Homo sapiens Q5XKR4
Y2H Prey Pooling
32296183
种属内
TPGS2 Q68CL5 OTP Homo sapiens Q5XKR4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypotrichosis 2

HYPT2

Hypotrichosis Simplex Of The Scalp 1

Htss1

Htss

Hypotrichosis, Spanish Type

Spanish Type Hypotrichosis

Hypotrichosis Spanish Type

Hypotrichosis, Type 2

Hypotrichosis Simplex Of Scalp
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14931 TPGS2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TPGS2 VGNC VGNC:36248
Mus musculus TPGS2 MGD MGI:1913898
Canis familiaris TPGS2 VGNC VGNC:47737
Rattus norvegicus TPGS2 RGD RGD:1310571
Macaca mulatta TPGS2 VGNC VGNC:79442
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