1. Gene
  2. CYP4X1 - cytochrome P450 family 4 subfamily X member 1 Gene

CYP4X1 - cytochrome P450 family 4 subfamily X member 1 Gene

中文名称:细胞色素 P450 家族 4 亚家族 X 成员 1

种属: Homo sapiens

同用名: CYPIVX1

基因 ID: 260293 | 基因类型: protein coding

关于 CYP4X1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,961,364-47,055,432 (from NCBI)

This gene has 2 transcripts (splice variants), 397 orthologues and 12 paralogues. Broad expression in prostate (RPKM 4.4), lung (RPKM 4.1) and 23 other tissues.

功能概要

该基因编码细胞色素 P450 酶超家族的一个成员,位于 1 号染色体上属于该超家族的一组基因中。细胞色素 P450 蛋白是单加氧酶,可催化许多参与药物代谢和胆固醇、类固醇和其他物质合成的反应脂质。类似大鼠蛋白质的表达模式表明该蛋白质可能参与大脑中的神经血管功能。可变剪接导致多个转录本变体。[RefSeq 提供,2016 年 2 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CYP4X1 基因产物(3)

mRNA Protein Name
NM_001320289.2 NP_001307218.1 cytochrome P450 4X1 isoform 2
NM_001320290.2 NP_001307219.1 cytochrome P450 4X1 isoform 3
NM_178033.2 NP_828847.1 cytochrome P450 4X1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables anandamide 14,15 epoxidase activity IDA
IDA: 通过直接分析推断
18549450 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CYP4X1 蛋白结构

p450

p450: Cytochrome P450 (47 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 509 a.a.
蛋白主名 其他名称

cytochrome P450 4X1

cytochrome P450, family 4, subfamily X, polypeptide 1

关联疾病

疾病名称 别名
Bietti Crystalline Corneoretinal Dystrophy

BCD

Bietti Crystalline Dystrophy

Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy

Bietti Crystalline Retinopathy

Bietti'S Crystalline Dystrophy

Crystalline Retinopathy

Dystrophy, Corneoretinal, Crystalline, Bietti

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CYP4X1 VGNC VGNC:103325
Macaca mulatta CYP4X1 VGNC VGNC:103614
Canis familiaris CYP4X1 VGNC VGNC:50372
Mus musculus CYP4X1 MGD MGI:1932403
Rattus norvegicus CYP4X1 RGD RGD:628719